ArticleScientific reports2021
Carvacrol exhibits rapid bactericidal activity against Streptococcus pyogenes through cell membrane damage.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed, 1 synthesis or guideline pooled it, 124 citations in OpenAlex.
- Supplementation of Probiotics in Pregnant Women Targeting Group B Streptococcus Colonization: A Systematic Review and Meta-Analysis.Nutrients · 2022Pooled it
- Iron-Reversible Bactericidal Activity of Marine-DerivedMarine drugs · 2026Article
- Probiotic-Plant Bioactive Synergy in Gut Health: Mechanisms, Antimicrobial Activity, and Translational Challenges.Nutrients · 2026Review
- Deciphering Neutral Ceramidase-Dependent Mechanism of Response to Aromatic Fungicides Stress inJournal of fungi (Basel, Switzerland) · 2026Article
- Pharmacological and mechanistic assessment of Trachyspermum ammi hydrosol: antimicrobial and anti-biofilm efficacy against Staphylococcus aureus and Listeria monocytogenes.Folia microbiologica · 2026Article
- Evaluation of plant-based antimicrobials in controlling antimicrobial resistance gene spread in poultry production continuum.Frontiers in veterinary science · 2026Article
- Antibacterial synergistic behaviour of phytosynthesized magnesium oxide nanoparticles with clove essential oil.Scientific reports · 2025Article
- Essential Oils in the Alternative Control of Postharvest Diseases in Strawberries: Anthracnose and Gray Mold.ACS omega · 2025Article
- Essential Oils from Wild AlbanianMolecules (Basel, Switzerland) · 2025Article
- Investigation of differential Multi-Mode antibacterial mechanisms of essential oils of Satureja montana L. and Leptospermum scoparium J.R.Forst. & G.Forst. Against Porphyromonas gingivalis.BMC complementary medicine and therapies · 2025Article
- Evaluation of Peptide-Based Vaccines AgainstVaccines · 2025Article
- Mechanisms of action and resistance prevention of synergistic thymol and carvacrol combinations with antibiotics in Staphylococcus aureus and Acinetobacter baumannii.Natural products and bioprospecting · 2025Article
- Lion's Mane Mushroom (Nutrients · 2025Review
- Essential Oils and their Active Constituents Effective against Non-growing Mycobacterium intracellulare.BMC complementary medicine and therapies · 2025Article
- Carvacrol and Streptomycin in Combination Weaken Streptomycin Resistance inPlants (Basel, Switzerland) · 2025Article
- Preparation and Efficacy of Microemulsion Carvacrol-Based Fruit and Vegetable Cleaner and Its Application on Cherry Tomatoes.Foods (Basel, Switzerland) · 2025Article
- Natural products in the treatment of diabetic foot infection.European journal of medical research · 2025Review
- Article
- Carvacrol alleviates LPS-induced myocardial dysfunction by inhibiting the TLR4/MyD88/NF-κB and NLRP3 inflammasome in cardiomyocytes.Journal of inflammation (London, England) · 2024Article
- Antifungal Effect of Oregano Essential Oil AgainstJournal of fungi (Basel, Switzerland) · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Streptococcus pyogenes is an important human pathogen worldwide. The identification of natural antibacterial phytochemicals has renewed interest due to the current scarcity of antibiotic development. Carvacrol is a monoterpenoid found in herbs. We evaluated carvacrol alone and combined with selected antibiotics against four strains of S. pyogenes in vitro. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of carvacrol against S. pyogenes were 125 µg/mL (0.53 mM) and 250 µg/mL (1.05 mM), respectively. Kill curve results showed that carvacrol exhibits instantaneous bactericidal activity against S. pyogenes. We also demonstrated the potential mechanism of action of carvacrol through compromising the cell membrane integrity. Carvacrol induced membrane integrity changes leading to leakage of cytoplasmic content such as lactate dehydrogenase enzymes and nucleic acids. We further confirmed dose-dependent rupturing of cells and cell deaths using transmission electron microscopy. The chequerboard assay results showed that carvacrol possesses an additive-synergistic effect with clindamycin or penicillin. Carvacrol alone, combined with clindamycin or penicillin, can be used as a safe and efficacious natural health product for managing streptococcal pharyngitis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.