ArticleNature communications2021
The challenges of containing SARS-CoV-2 via test-trace-and-isolate.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
89 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association Between Rapid Antigen Detection Tests and Real-Time Reverse Transcription-Polymerase Chain Reaction Assay for SARS-CoV-2: A Systematic Review and Meta-Analyses.International journal of public health · 2023Pooled it
- Optimizing infectious disease mitigation under dynamic conditions.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Mechanics of pandemics.EClinicalMedicine · 2026Review
- Infection control challenges during 4 years of COVID-19 in a French psychiatric institution (2020-2024).IJID regions · 2026Article
- Assessing the effectiveness of test-trace-isolate interventions using a multi-layered temporal network.Infectious Disease Modelling · 2025Article
- Understanding Nash epidemics.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Review
- Key factors determining the development of SARS-CoV-2 testing strategies in EU countries: a mixed-methods study.BMJ public health · 2025Article
- A novel, scenario-based approach to comparing non-pharmaceutical intervention strategies across nations.Journal of the Royal Society, Interface · 2024Article
- Effectiveness of probabilistic contact tracing in epidemic containment: The role of superspreaders and transmission path reconstruction.PNAS nexus · 2024Article
- Psychological factors associated with Long COVID: a systematic review and meta-analysis.EClinicalMedicine · 2024Article
- A mathematical model to assess the effectiveness of test-trace-isolate-and-quarantine under limited capacities.PloS one · 2024Article
- Article
- A network meta-analysis of risk factors of infection among close contacts of COVID-19.Heliyon · 2023Article
- Evaluating the impact of test-trace-isolate for COVID-19 management and alternative strategies.PLoS computational biology · 2023Article
- Detection of SARS-CoV-2 Based on Nucleic Acid Amplification Tests (NAATs) and Its Integration into Nanomedicine and Microfluidic Devices as Point-of-Care Testing (POCT).International journal of molecular sciences · 2023Review
- Scalable RT-LAMP-based SARS-CoV-2 testing for infection surveillance with applications in pandemic preparedness.EMBO reports · 2023Article
- Optimal strategies for coordinating infection control and socio-economic activities.Mathematics and computers in simulation · 2023Article
- Mobile SARS‑CoV‑2 screening facilities for rapid deployment and university-based diagnostic laboratory.Engineering in life sciences · 2023Article
- Impact of the Euro 2020 championship on the spread of COVID-19.Nature communications · 2023Article
29 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Without a cure, vaccine, or proven long-term immunity against SARS-CoV-2, test-trace-and-isolate (TTI) strategies present a promising tool to contain its spread. For any TTI strategy, however, mitigation is challenged by pre- and asymptomatic transmission, TTI-avoiders, and undetected spreaders, which strongly contribute to "hidden" infection chains. Here, we study a semi-analytical model and identify two tipping points between controlled and uncontrolled spread: (1) the behavior-driven reproduction number [Formula: see text] of the hidden chains becomes too large to be compensated by the TTI capabilities, and (2) the number of new infections exceeds the tracing capacity. Both trigger a self-accelerating spread. We investigate how these tipping points depend on challenges like limited cooperation, missing contacts, and imperfect isolation. Our results suggest that TTI alone is insufficient to contain an otherwise unhindered spread of SARS-CoV-2, implying that complementary measures like social distancing and improved hygiene remain necessary.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.