Evidence map›Paper›PMID 33452226›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2021

The Wnt Effector TCF7l2 Promotes Oligodendroglial Differentiation by Repressing Autocrine BMP4-Mediated Signaling.

Sheng Zhang, Yan Wang, Xiaoqing Zhu, Lanying Song, Xinhua Zhan, Edric Ma, Jennifer McDonough, Hui Fu, Franca Cambi, Judith Grinspan and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 39 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Oligodendrocyte-specific expression ofNon-coding RNA research · 2024
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 2 countries.

Sheng ZhangDepartment of Neurology, School of Medicine, University of California, Davis, California, 95817.ORCID 0000-0002-0692-8999
Yan WangDepartment of Neurology, School of Medicine, University of California, Davis, California, 95817.
Xiaoqing ZhuDepartment of Neurology, School of Medicine, University of California, Davis, California, 95817.
Lanying SongDepartment of Neurology, School of Medicine, University of California, Davis, California, 95817.
Xinhua ZhanDepartment of Neurology, School of Medicine, University of California, Davis, California, 95817.
Edric MaDepartment of Neurology, School of Medicine, University of California, Davis, California, 95817.
Jennifer McDonoughDepartment of Biological Sciences, Kent State University, Kent, Ohio, 44242.
Hui FuDivision of Life Sciences and Medicine, School of Basic Medical Sciences, University of Science and Technology of China, Anhui, China, 230027.
Franca CambiDepartment of Neurology, Pittsburgh University, Pittsburgh, Pennsylvania, 15260.
Judith GrinspanDepartment of Neurology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, 19104.ORCID 0000-0003-0940-5314
Fuzheng GuoDepartment of Neurology, School of Medicine, University of California, Davis, California, 95817 fzguo@ucdavis.edu.ORCID 0000-0003-3410-8389
Shriners Hospitals for Children - Erie · USChildren's Hospital of Philadelphia · USKent State University · USUniversity of California, Davis · USUniversity of Pittsburgh · USUniversity of Science and Technology of China · CN

Funding

The Wnt-independent role of TCF7l2 in CNS myelin formation and repairR01NS094559 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI GUO, FUZHENG · 2016 to 2020
$1.4M
A paradigm shift in our understanding of oligodendroglial HIFa-regulated CNS angiogenesisR21NS109790 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI GUO, FUZHENG · 2018 to 2019
$432k
NINDS NIH HHS R01 NS094559NINDS NIH HHS R21 NS109790
6 · The paper itself

Abstract

Promoting oligodendrocyte (OL) differentiation represents a promising option for remyelination therapy for treating the demyelinating disease multiple sclerosis (MS). The Wnt effector transcription factor 7-like 2 (TCF7l2) was upregulated in MS lesions and had been proposed to inhibit OL differentiation. Recent data suggest the opposite yet underlying mechanisms remain elusive. Here, we unravel a previously unappreciated function of TCF7l2 in controlling autocrine bone morphogenetic protein (BMP)4-mediated signaling. Disrupting TCF7l2 in mice of both sexes results in oligodendroglial-specific BMP4 upregulation and canonical BMP4 signaling activation

Indexed as

AnimalsAutocrine CommunicationBone Morphogenetic Protein 4BrainCell DifferentiationGene Expression RegulationMiceMice, Inbred C57BLMice, TransgenicNeurogenesisOligodendrocyte Precursor CellsOligodendrogliaTranscription Factor 7-Like 2 ProteinBmp4 protein, mouseBone Morphogenetic Protein 4Tcf7l2 protein, mouseTranscription Factor 7-Like 2 ProteinBMP4 repressioncanonical Wnt/β-cateninmyelinationoligodendrocyte differentiationTCF7l2/TCF4Wnt effector

Identifiers

PMID33452226
PMCPMC8115879
OpenAlexW3124209384

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.