ArticleProceedings of the National Academy of Sciences of the United States of America2021
OCT4 induces embryonic pluripotency via STAT3 signaling and metabolic mechanisms.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 65 citations in OpenAlex.
- The transcription factor THAP11 is a general regulator of early embryonic polarization.bioRxiv : the preprint server for biology · 2026Article
- SOCS3 deficiency drives the primed to naive pluripotency transition by sustaining STAT3 activation.Frontiers in genetics · 2026Article
- Lactate Promotes the Second Cell Fate Decision in Blastocysts by Prompting Primitive Endoderm Formation Through an Intercellular Positive Feedback Loop That Couples Paracrine FGF Signalling.Cell proliferation · 2025Article
- α-Ketoglutarate promotes trophectoderm induction and maturation from naive human embryonic stem cells.Nature cell biology · 2025Article
- Crosstalk between Signaling Pathways and Energy Metabolism in Pluripotency.International journal of stem cells · 2025Review
- Emerging cooperativity between Oct4 and Sox2 governs the pluripotency network in early mouse embryos.eLife · 2025Article
- The transcription factor GABPA is a master regulator of naive pluripotency.Nature cell biology · 2025Article
- Coupling of stemness maintenance with cell cycle control in stem cells.Frontiers in cell and developmental biology · 2025Review
- Deep learning-based models for preimplantation mouse and human embryos based on single-cell RNA sequencing.Nature methods · 2025Article
- Signaling pathway regulators in preimplantation embryos.Journal of molecular histology · 2024Review
- Induction of Pluripotent Stem Cells from Muscle Cells of Large Yellow Croaker (Larimichthys Crocea) Via Electrotransfection.Marine biotechnology (New York, N.Y.) · 2024Article
- The transcription factor GABPA is a master regulator of naïve pluripotency.bioRxiv : the preprint server for biology · 2024Article
- Article
- Lineage regulators TFAP2C and NR5A2 function as bipotency activators in totipotent embryos.Nature structural & molecular biology · 2024Article
- The effect of data transformation on low-dimensional integration of single-cell RNA-seq.BMC bioinformatics · 2024Article
- The role of lipids in genome integrity and pluripotency.Biochemical Society transactions · 2024Review
- Txnip regulates the Oct4-mediated pluripotency circuitry via metabolic changes upon differentiation.Cellular and molecular life sciences : CMLS · 2024Article
- A 3D "sandwich" co-culture system with vascular niche supports mouse embryo development from E3.5 to E7.5 in vitro.Stem cell research & therapy · 2023Article
- insideOutside: an accessible algorithm for classifying interior and exterior points, with applications in embryology.Biology open · 2023Article
- Notch and Wnt Signaling Modulation to Enhance DPSC Stemness and Therapeutic Potential.International journal of molecular sciences · 2023Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
OCT4 is a fundamental component of the molecular circuitry governing pluripotency in vivo and in vitro. To determine how OCT4 establishes and protects the pluripotent lineage in the embryo, we used comparative single-cell transcriptomics and quantitative immunofluorescence on control and OCT4 null blastocyst inner cell masses at two developmental stages. Surprisingly, activation of most pluripotency-associated transcription factors in the early mouse embryo occurs independently of OCT4, with the exception of the JAK/STAT signaling machinery. Concurrently, OCT4 null inner cell masses ectopically activate a subset of trophectoderm-associated genes. Inspection of metabolic pathways implicates the regulation of rate-limiting glycolytic enzymes by OCT4, consistent with a role in sustaining glycolysis. Furthermore, up-regulation of the lysosomal pathway was specifically detected in OCT4 null embryos. This finding implicates a requirement for OCT4 in the production of normal trophectoderm. Collectively, our findings uncover regulation of cellular metabolism and biophysical properties as mechanisms by which OCT4 instructs pluripotency.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.