ArticleScience immunology2021
Inhibitory signaling sustains a distinct early memory CD8
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Article in Science immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
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63citing papers in PubMed
5.1field-weighted citation impact, top 3% of its field
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Who cites it
63 citing papers in PubMed, 81 citations in OpenAlex.
- Combined JAK inhibition and PD-1 immunotherapy for non-small cell lung cancer patients.Science (New York, N.Y.) · 2024Trial
- CD8Cell reports. Medicine · 2026Review
- Tobemstomig, a Novel Bispecific Antibody, Preferentially Blocks PD-1 and LAG-3 on CD8 TILs to Expand Stem-like T Cells for Sustained Tumor Control.Cancer research communications · 2026Article
- BATF3 regulates differentiation of CD8Life science alliance · 2026Article
- Granzyme A-expressing Terminal Effector T Cells Dedifferentiate into Long-lived Memory T Cells.Research square · 2026Article
- ATR kinase inhibitors induce mitochondrial fission in CD8bioRxiv : the preprint server for biology · 2026Article
- Targeting Mettl8-Tcf1 axis promotes CD8+ TPEX differentiation and antitumor immunity.The Journal of experimental medicine · 2026Article
- Sensing of DNA double-strand breaks by the NHEJ system stabilizes RORγt transcriptional activity and shapes Th17 pathogenicity in autoimmunity.Cell research · 2026Article
- Nur77 Is Associated With Polyfunctional Properties in Virus-Specific Human CD8European journal of immunology · 2026Article
- Stem-like PD-1Journal for immunotherapy of cancer · 2026Article
- Oncolytic virotherapy potentiates chemo-PD-1 immunotherapy by engaging chemo-resistant bystander CD8Journal for immunotherapy of cancer · 2026Article
- Metabolic quiescence of naive-like memory T cells precedes and maintains antigen-specific T cell memory.Nature immunology · 2026Article
- Glutamine synthetase deficiency enhances CD8 T cell survival and stress resilience in the tumor microenvironment.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Regulation of T cell exhaustion and stemness: molecular mechanisms and implications for cancer immunotherapy.Cellular & molecular immunology · 2026Review
- Pre-division TCF1 drop determines long-term CD8 T cell fates.bioRxiv : the preprint server for biology · 2025Article
- Metabolic and proteomic signatures differentiate inflammatory phenotypes from cancer and predict treatment response in patient sera.Bioengineering & translational medicine · 2025Article
- Lymphatic chain gradients regulate the magnitude and heterogeneity of T cell responses to vaccination.The Journal of experimental medicine · 2025Article
- Prolonged but finite antigen presentation promotes reversible defects of "helpless" memory CD8Immunity · 2025Article
- Immune regeneration: implications for cancer immunotherapy and beyond.The Journal of clinical investigation · 2025Review
- Mitochondrial response to fever boosts TImmunometabolism (Cobham, Surrey) · 2025Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
28 authors at 12 institutions in 4 countries.
Jonathan B JohnnidisDepartment of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0003-4308-2504
Yuki MuroyamaDepartment of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0001-9839-6370
Shin Foong NgiowDepartment of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-5738-2834
Zeyu ChenDepartment of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA.
Sasikanth ManneDepartment of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0001-9856-0871
Zhangying CaiDivision of Biology and Biomedical Sciences, Washington University, St. Louis, MO 63110, USA.
Shufei SongDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0003-3084-8013
Jesse M PlattDivision of Gastroenterology, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
Jason M SchenkelDepartment of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA.ORCID 0000-0003-4641-6872
Mohamed Abdel-HakeemDepartment of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0003-0226-3464
Jean-Christophe BeltraDepartment of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-6363-3572
Allison R GreenplateDepartment of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-2614-3072
Mohammed-Alkhatim A AliDepartment of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA.
Kito NzinghaDepartment of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-8839-5208
Josephine R GilesDepartment of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-3713-338X
Christelle HarlyT-Cell Biology and Development Unit, Laboratory of Genome Integrity, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.ORCID 0000-0002-8045-9166
John AttanasioInstitute for Immunology, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0001-7498-1452
Kristen E PaukenDepartment of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-4309-7880
Bertram BengschDepartment of Medicine II, Gastroenterology, Hepatology, Endocrinology, and Infectious Diseases, University Medical Center Freiburg, Germany.ORCID 0000-0003-2552-740X
Michael A PaleyDepartment of Medicine, Washington University in Saint Louis School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0001-8724-3176
Vesselin T TomovInstitute for Immunology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Makoto KurachiDepartment of Molecular Genetics, Graduate School of Medicine, Kanazawa University, Kanazawa, Japan.ORCID 0000-0002-7202-7822
Dario A A VignaliDepartment of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.ORCID 0000-0002-2771-5992
Arlene H SharpeDepartment of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-9736-2109
Steven L ReinerDepartment of Microbiology and Immunology and Department of Pediatrics, Columbia University, New York, NY 10032, USA.ORCID 0000-0002-1635-8619
Avinash BhandoolaT-Cell Biology and Development Unit, Laboratory of Genome Integrity, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.ORCID 0000-0002-4657-8372
F Bradley JohnsonDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-7443-7227
E John WherryDepartment of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA. wherry@pennmedicine.upenn.edu.ORCID 0000-0003-0477-1956
Translational Therapeutics (United States) · USParker Institute for Cancer Immunotherapy · USUniversity of Pennsylvania · USBrigham and Women's Hospital · USWashington University in St. Louis · USCentre National de la Recherche Scientifique · FRColumbia University · USKanazawa University · JPMassachusetts General Hospital · USNational Cancer Institute · USUniversity of Freiburg · DEUniversity of Pittsburgh · US
Funding
Virology CoreU19AI082630 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI RAYMOND T CHUNG, GEORG Michael LAUER · 2009 to 2026
$48.1MTransgenic/KnockoutP01AI056299 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI SHARPE, ARLENE H. · 2003 to 2023
$42.5MSynergies among inhibitory receptors in tolerance, cancer & antiviral immunityP01AI108545 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI E. John Wherry · 2015 to 2026
$30.8MT cell Development and RegenerationZIABC011633 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI BHANDOOLA, AVINASH · 2015 to 2025
$20.5MIMMUNOBIOLOGY OF NORMAL AND NEOPLASTIC LYMPHOCYTEST32CA009140 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Malay Haldar, WARREN S PEAR · 1985 to 2026
$16.1MRESEARCH TRAINING IN DIGESTIVE DISEASES AND NUTRITIONT32DK007191 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI RAYMOND T CHUNG · 1986 to 2026
$14.6MModeling HIV CAR-T cell trafficking and persistence in Non-Human PrimatesU19AI149680 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI RILEY, JAMES L. · 2020 to 2024
$13.2MSequencing and Viral Evolution CoreU19AI117950 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI WHERRY, E. JOHN · 2015 to 2019
$12.0MRadiation and checkpoint blockade for cancer immune therapyP01CA210944 · NCI · UNIVERSITY OF PENNSYLVANIA · PI KOUMENIS, CONSTANTINOS · 2017 to 2022
$11.5MP3: Chemokine-Mediated T Cell Trafficking in HIV Transmission and Immune ResponseP01AI112521 · NIAID · HARVARD MEDICAL SCHOOL · PI LUSTER, ANDREW · 2014 to 2018
$9.8MTesting the role of BATF as a pioneer transcription factor in effector T cellsR01AI115712 · NIAID · DANA-FARBER CANCER INST · PI KADOCH, CIGALL, WHERRY, E. JOHN · 2015 to 2019
$2.9MCellular and transcriptional control of exhausted CD8 T cells lineage dynamicsR01AI105343 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI WHERRY, E. JOHN · 2014 to 2017
$1.6MNCI NIH HHS P01 CA210944NCI NIH HHS T32 CA009140NIAID NIH HHS P01 AI056299NIAID NIH HHS P01 AI108545NIAID NIH HHS P01 AI112521NIAID NIH HHS R01 AI105343NIAID NIH HHS R01 AI115712NIAID NIH HHS T32 AI070099NIAID NIH HHS U19 AI082630NIAID NIH HHS U19 AI117950NIAID NIH HHS U19 AI149680NIDDK NIH HHS T32 DK007191
Abstract
The developmental origins of memory T cells remain incompletely understood. During the expansion phase of acute viral infection, we identified a distinct subset of virus-specific CD8
Indexed as
AnimalsAntigens, CDCD8-Positive T-LymphocytesCell DifferentiationDisease Models, AnimalDNA DamageFemaleHepatocyte Nuclear Factor 1-alphaHumansImmunologic MemoryListeria monocytogenesListeriosisLymphocyte ActivationLymphocyte Activation Gene 3 ProteinLymphocytic ChoriomeningitisLymphocytic choriomeningitis virusAntigens, CDHepatocyte Nuclear Factor 1-alphaHnf1a protein, mouseLymphocyte Activation Gene 3 ProteinPdcd1 protein, mouseProgrammed Cell Death 1 Receptor
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.