ArticleJournal of neurology, neurosurgery, and psychiatry2021
Modelling the cascade of biomarker changes in
Article in Journal of neurology, neurosurgery, and psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Pre-symptomatic radiological changes in frontotemporal dementia: propagation characteristics, predictive value and implications for clinical trials.Brain imaging and behavior · 2022Pooled it
- Disrupted interhemispheric communication in primary progressive aphasia: a multimodal MRI study of homotopic connectivity.NeuroImage. Clinical · 2026Article
- Mapping the multiscale neuroanatomy of GRN-related frontotemporal dementia using mode-based morphometry.NeuroImage. Clinical · 2026Article
- Update on Disease-Modifying Pharmacological Treatments for Frontotemporal Dementia (FTD): A Scoping Review of Registered Trials.NeuroSci · 2025Review
- White matter hyperintensities precede other biomarkers in GRN frontotemporal dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Functional Impairment in Behavioral Variant Frontotemporal Dementia: Cognitive, Behavioral, Personality, and Brain Perfusion Contributions.Journal of personalized medicine · 2025Article
- Fluid biomarkers in familial frontotemporal dementia: progress and prospects.Frontiers in neurology · 2025Review
- Changes in Digital Speech Measures in Asymptomatic Carriers of Pathogenic Variants Associated With Frontotemporal Degeneration.Neurology · 2024Article
- Characterization of Progranulin Gene Mutations in Portuguese Patients with Frontotemporal Dementia.International journal of molecular sciences · 2023Article
- Clinical Value of Longitudinal Serum Neurofilament Light Chain in Prodromal Genetic Frontotemporal Dementia.Neurology · 2023Observational
- Frontotemporal lobar degeneration.Nature reviews. Disease primers · 2023Review
- The role of neurofilament light in genetic frontotemporal lobar degeneration.Brain communications · 2023Review
- Temporal order of clinical and biomarker changes in familial frontotemporal dementia.Nature medicine · 2022Article
- Biomarker discovery and development for frontotemporal dementia and amyotrophic lateral sclerosis.Brain : a journal of neurology · 2022Review
- A data-driven disease progression model of fluid biomarkers in genetic frontotemporal dementia.Brain : a journal of neurology · 2022Article
- Data-driven staging of genetic frontotemporal dementia using multi-modal MRI.Human brain mapping · 2022Article
- The Advance on Frontotemporal Dementia (FTD)'s Neuropathology and Molecular Genetics.Mediators of inflammation · 2022Review
- Differences and similarities between familial and sporadic frontotemporal dementia: An Italian single-center cohort study.Alzheimer's & dementia (New York, N. Y.) · 2022Article
- Plasma NfL levels and longitudinal change rates inJournal of neurology, neurosurgery, and psychiatry · 2021Article
- Prodromal frontotemporal dementia: clinical features and predictors of progression.Alzheimer's research & therapy · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
24 authors at 6 institutions in 4 countries.
Funding
Abstract
objectiveProgranulin-related frontotemporal dementia (FTD-
methodsWe included 56 presymptomatic and 35 symptomatic
resultsLanguage functioning and NfL were the earliest abnormal biomarkers in FTD-
conclusionDegeneration of axons and language deficits are indicated to be the earliest biomarkers in FTD-
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.