Evidence map›Paper›PMID 33452028›Full record

ArticleApplied and environmental microbiology2021

Anaerobic Production of Isoprene by Engineered

Jared Aldridge, Sean Carr, Karrie A Weber, Nicole R Buan

Open access · greenAbstract read
In one paragraph

Article in Applied and environmental microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 35 citations in OpenAlex.

  1. Valine overproduction inMetabolic engineering communications · 2026
    Article
  2. Article
  3. Cell surface differences within the genusJournal of bacteriology · 2025
    Review
  4. Article
  5. Mer overexpression inApplied and environmental microbiology · 2025
    Article
  6. Article
  7. Article
  8. A hybrid photocatalytic system enables direct glucose utilization for methanogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  9. Review
  10. CRISPR/Cas12a toolbox for genome editing inFrontiers in microbiology · 2023
    Article
  11. Methods for Culturing Anaerobic Microorganisms.Methods in molecular biology (Clifton, N.J.) · 2023
    Article
  12. Article
  13. MICROBIAL isoprene production: an overview.World journal of microbiology & biotechnology · 2022
    Review
  14. Article
  15. Insights into the biotechnology potential ofFrontiers in microbiology · 2022
    Review
  16. Article
  17. Article
  18. Diversifying Isoprenoid PlatformsFrontiers in microbiology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jared AldridgeDepartment of Biochemistry, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.
Sean CarrDepartment of Biochemistry, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.
Karrie A WeberSchool of Biological Sciences, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.ORCID 0000-0002-0457-658X
Nicole R BuanDepartment of Biochemistry, University of Nebraska-Lincoln, Lincoln, Nebraska, USA nbuan2@unl.edu.ORCID 0000-0002-7560-973X
University of Nebraska–Lincoln · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Isoprene is a valuable petrochemical used for a wide variety of consumer goods, such as adhesives and synthetic rubber. We were able to achieve a high yield of renewable isoprene by taking advantage of the naturally high-flux mevalonate lipid synthesis pathway in anaerobic methane-producing archaea (methanogens). Our study illustrates that by genetically manipulating

Indexed as

AnaerobiosisButadienesHemiterpenesMethanolMethanosarcinaMevalonic AcidMicroorganisms, Genetically-ModifiedButadienesHemiterpenesisopreneMethanolMevalonic AcidarchaeaisopreneisoprenogenisoprenoidsispSmetabolic engineeringmethanogenmethanogenesisMethanosarcina acetivoransMethanosarcina barkerimevalonatemevalonate pathwaysynthetic biology

Identifiers

PMID33452028
PMCPMC8104995
OpenAlexW3118639423

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.