Evidence map›Paper›PMID 33451316›Full record

ArticleBMC pulmonary medicine2021

Severe pneumonia in adults caused by Tropheryma whipplei and Candida sp. infection: a 2019 case series.

Wei Li, Qun Zhang, Yanling Xu, Xiyue Zhang, Qian Huang, Zhenzhong Su

Open access · goldAbstract readCase Reports
In one paragraph

Article in BMC pulmonary medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 32 citations in OpenAlex.

  1. Diagnostics (Basel, Switzerland) · 2026
    Article
  2. Pulmonary infection caused byTranslational pediatrics · 2026
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  3. PulmonaryRespirology case reports · 2026
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  4. Article
  5. Frontiers in medicine · 2026
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  6. Review
  7. Severe and Rapid Progression ofRespirology case reports · 2025
    Article
  8. Article
  9. A Rare Case Report ofInfection and drug resistance · 2025
    Article
  10. Respiratory medicine case reports · 2025
    Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Co-infection ofWorld journal of clinical cases · 2023
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Wei LiDepartment of Respiratory and Critical Care Medicine, The Second Hospital of Jilin University, Changchun, Jilin, China.
Qun ZhangDepartment of Respiratory and Critical Care Medicine, The Second Hospital of Jilin University, Changchun, Jilin, China.
Yanling XuDepartment of Respiratory and Critical Care Medicine, The Second Hospital of Jilin University, Changchun, Jilin, China.
Xiyue ZhangDepartment of Respiratory and Critical Care Medicine, The Second Hospital of Jilin University, Changchun, Jilin, China.
Qian HuangDepartment of Radiology, The Second Hospital of Jilin University, Changchun, Jilin, China.
Zhenzhong SuDepartment of Respiratory and Critical Care Medicine, The Second Hospital of Jilin University, Changchun, Jilin, China. su_zhenzhong@163.com.
Second Affiliated Hospital of Jilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWhipple's disease is a chronic infectious disease caused by the Gram-positive bacterium Tropheryma whipplei (TW), which not only affects the gastrointestinal tract and causes malabsorption of nutrients, but several other systems, such as the cardiovascular system, central nervous system, the joints, and the vascular system, can also be simultaneously involved. The aim of this report was to be able to alert the clinician to severe pneumonia caused by TW combined with Candida sp. CASE PRESENTATION: The case study was conducted on patients in September and November 2019. After routine examination and treatment, the results were not satisfactory. A bronchoalveolar lavage (BAL) using metagenomics next-generation sequencing was conducted on two adults who presented with fever, cough, and progressive dyspnea and who had no history of gastrointestinal symptoms, immunodeficiency diseases, or use of immunosuppressive agents. TW and Candida sp. were detected in in BAL.

conclusionsThis is a report of life-threatening pneumonia caused by TW combined with Candida sp. in a Chinese population.

Indexed as

AdultAged, 80 and overBronchoalveolar Lavage FluidCandidaCandidiasisFemaleHigh-Throughput Nucleotide SequencingHumansMalePneumoniaTomography, X-Ray ComputedTropherymaWhipple DiseaseBronchoalveolar lavageCandidaMetagenomics next-generation sequencingPneumoniaTropheryma whipplei

Identifiers

PMID33451316
PMCPMC7810182
OpenAlexW3124589620

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.