Evidence map›Paper›PMID 33451158›Full record

ArticlePharmaceutics2021

Impact of DOTA Conjugation on Pharmacokinetics and Immunoreactivity of [

Judith Anna Delage, Alain Faivre-Chauvet, Jacques Barbet, Julie Katrin Fierle, Niklaus Schaefer, George Coukos, David Viertl, Steven Mark Dunn, Silvano Gnesin, John O Prior

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

  1. Challenges in tracer development for tumor microenvironment (TME) imaging.European journal of nuclear medicine and molecular imaging · 2026
    Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. From bench to bedside:EJNMMI research · 2023
    Article
  10. Toward OptimizedPharmaceutics · 2022
    Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Judith Anna DelageRadiopharmacy Unit, Department of Pharmacy, Lausanne University Hospital and University of Lausanne, CH-1011 Lausanne, Switzerland.
Alain Faivre-ChauvetCRCINA, INSERM 1232-CNRS ERL 6001, University of Angers, University of Nantes, 44000 Nantes, France.
Jacques BarbetGroupement d'Intérêt Public Arronax, F-44800 Saint-Herblain, France.ORCID 0000-0002-9188-984X
Julie Katrin FierleLAbCore, Ludwig Institute for Cancer Research, Lausanne University Hospital and University of Lausanne, CH-1066 Epalinges, Switzerland.
Niklaus SchaeferDepartment of Nuclear Medicine and Molecular Imaging, Lausanne University Hospital and University of Lausanne, CH-1011 Lausanne, Switzerland.
George CoukosLudwig Institute for Cancer Research and Department of Oncology, Lausanne University Hospital and University of Lausanne, CH-1011 Lausanne, Switzerland.
David ViertlDepartment of Nuclear Medicine and Molecular Imaging, Lausanne University Hospital and University of Lausanne, CH-1011 Lausanne, Switzerland.
Steven Mark DunnLAbCore, Ludwig Institute for Cancer Research, Lausanne University Hospital and University of Lausanne, CH-1066 Epalinges, Switzerland.
Silvano GnesinInstitute of Radiation Physics, Lausanne University Hospital and University of Lausanne, CH-1011 Lausanne, Switzerland.ORCID 0000-0002-6547-3824
John O PriorDepartment of Nuclear Medicine and Molecular Imaging, Lausanne University Hospital and University of Lausanne, CH-1011 Lausanne, Switzerland.ORCID 0000-0003-1429-1374
University of Lausanne · CHLudwig Cancer Research · CHCentre National de la Recherche Scientifique · FRDeleted Institution

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

1C1m-Fc, an anti-tumor endothelial marker 1 (TEM-1) scFv-Fc fusion protein antibody, was previously successfully radiolabeled with

Indexed as

177Lu radiolabelingbiodistributionDOTA conjugationfusion protein antibodyTEM-1theranostictumor/liver ratio

Identifiers

PMID33451158
PMCPMC7828678
OpenAlexW3119204130

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.