Evidence map›Paper›PMID 33451132›Full record

ArticleViruses2021

Systematic Search for SARS-CoV-2 Main Protease Inhibitors for Drug Repurposing: Ethacrynic Acid as a Potential Drug.

Camilla Isgrò, Anna Maria Sardanelli, Luigi Leonardo Palese

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Therapeutic dilemmas in addressing SARS-CoV-2 infection: Favipiravir versus Remdesivir.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022
    Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Camilla IsgròDepartment of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari Aldo Moro, Piazza G. Cesare 11, 70124 Bari, Italy.ORCID 0000-0002-9981-4121
Anna Maria SardanelliDepartment of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari Aldo Moro, Piazza G. Cesare 11, 70124 Bari, Italy.ORCID 0000-0002-8535-7601
Luigi Leonardo PaleseDepartment of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari Aldo Moro, Piazza G. Cesare 11, 70124 Bari, Italy.ORCID 0000-0002-3447-1535
Università Campus Bio-Medico · ITUniversity of Bari Aldo Moro · IT

Funding

Universita degli Studi di Bari Aldo Moro N/A
6 · The paper itself

Abstract

In 2019 an outbreak occurred which resulted in a global pandemic. The causative agent has been identified in a virus belonging to the

Indexed as

Antiviral AgentsCatalytic DomainCoronavirus 3C ProteasesDatabases, FactualDrug RepositioningEthacrynic AcidInhibitory Concentration 50Molecular Docking SimulationProtease InhibitorsSARS-CoV-2Antiviral AgentsCoronavirus 3C ProteasesEthacrynic AcidProtease Inhibitors3C-like protease3CL proteasecoronavirusCOVID-19drug repurposingmain proteaseMproprotease inhibitorsSARS-CoV-2

Identifiers

PMID33451132
PMCPMC7828626
OpenAlexW3120030087

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.