Evidence map›Paper›PMID 33451122›Full record

ArticleInternational journal of molecular sciences2021

Phosphodiesterase Type-5 Inhibitor Tadalafil Modulates Steroid Hormones Signaling in a Prostate Cancer Cell Line.

Viviana M Bimonte, Francesco Marampon, Ambra Antonioni, Simona Fittipaldi, Elisabetta Ferretti, Richard G Pestell, Mariaignazia Curreli, Andrea Lenzi, Giovanni Vitale, Antonio Brunetti and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 2 countries.

Viviana M BimonteDepartment of Movement, Human and Health Sciences, "Foro Italico" University, 00135 Rome, Italy.
Francesco MaramponDepartment of Radiological, Oncological and Pathological Sciences, "Sapienza" University, 00161 Rome, Italy.
Ambra AntonioniDepartment of Experimental Medicine, "Sapienza" University of Rome, 00161 Rome, Italy.
Simona FittipaldiDepartment of Biomedicine and Prevention, "Tor Vergata" University, 00133 Rome, Italy.ORCID 0000-0001-7578-395X
Elisabetta FerrettiDepartment of Experimental Medicine, "Sapienza" University of Rome, 00161 Rome, Italy.ORCID 0000-0001-7265-6429
Richard G PestellPennsylvania Cancer and Regenerative Medicine Research Center, Baruch S. Blumberg Institute, Pennsylvania Biotechnology Center, Wynnewood, PA 19111, USA.ORCID 0000-0003-3244-8777
Mariaignazia CurreliDepartment of Experimental Medicine, "Sapienza" University of Rome, 00161 Rome, Italy.
Andrea LenziDepartment of Experimental Medicine, "Sapienza" University of Rome, 00161 Rome, Italy.
Giovanni VitaleDepartment of Medical Biotechnologies and Translational Medicine, University of Milan, 20122 Milan, Italy.ORCID 0000-0003-2478-683X
Antonio BrunettiDepartment of Health Sciences, Magna Graecia University, 88100 Catanzaro, Italy.ORCID 0000-0003-1533-8779
Silvia MigliaccioDepartment of Movement, Human and Health Sciences, "Foro Italico" University, 00135 Rome, Italy.ORCID 0000-0002-4563-6630
Antonio AversaDepartment of Experimental and Clinical Medicine, Magna Græcia University, 88100 Catanzaro, Italy.ORCID 0000-0002-2989-2618
Sapienza University of Rome · ITForo Italico University of Rome · ITMagna Graecia University · ITBaruch S. Blumberg Institute · USUniversity of Milan · ITUniversity of Rome Tor Vergata · IT

Funding

Agenzia Italiana del Farmaco, Ministero della Salute 2015XCR88M_008Agenzia Italiana del Farmaco, Ministero della Salute 2017HBHA98
6 · The paper itself

Abstract

backgroundThe androgen receptor (AR) plays a key role in normal prostate homeostasis and in prostate cancer (PCa) development, while the role of aromatase (Cyp19a1) is still unclear. We evaluated the effects of a treatment with Tadalafil (TAD) on both these proteins.

methodsAndrogen-sensitive human PCa cell line (LnCAP) was incubated with/without TAD (10

resultsTAD increased early AR nuclear translocation (

conclusionWe demonstrate for the first time that TAD can significantly modulate AR expression and activity, Cyp19a1 and ERβ expression in PCa cells, suggesting a specific effect of these proteins. In addition, TAD potentiates the antiproliferative activity of BCT, opening a new clinical scenario in the treatment of PCa.

Indexed as

BiomarkersCell Line, TumorCell ProliferationCell SurvivalDrug Resistance, NeoplasmGene Expression ProfilingGene Expression Regulation, NeoplasticHormonesHumansMalePhosphodiesterase 5 InhibitorsProstatic NeoplasmsProtein TransportReceptors, AndrogenSignal TransductionSteroidsAR protein, humanBiomarkersHormonesPhosphodiesterase 5 InhibitorsReceptors, AndrogenSteroidsTadalafilandrogen resistancearomatasebicalutamideprostate cancertadalafil

Identifiers

PMID33451122
PMCPMC7828628
OpenAlexW3119391743

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.