Evidence map›Paper›PMID 33451062›Full record

ArticleJournal of fungi (Basel, Switzerland)2021

In Vitro and In Vivo Effect of Peptides Derived from 14-3-3

Liliana Scorzoni, Ana Carolina Alves de Paula E Silva, Haroldo Cesar de Oliveira, Claudia Tavares Dos Santos, Junya de Lacorte Singulani, Patricia Akemi Assato, Caroline Maria Marcos, Lariane Teodoro Oliveira, Nathália Ferreira Fregonezi, Diego Conrado Pereira Rossi and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of fungi (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Computational Approaches for Discovering Virulence Factors inJournal of fungi (Basel, Switzerland) · 2025
    Review
  2. Role of paracoccin onVirulence · 2023
    Article
  3. Polypeptides TargetingJournal of fungi (Basel, Switzerland) · 2023
    Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Liliana ScorzoniSchool of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara, São Paulo 14800-903, Brazil.ORCID 0000-0002-0178-6653
Ana Carolina Alves de Paula E SilvaSchool of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara, São Paulo 14800-903, Brazil.ORCID 0000-0001-5296-1514
Haroldo Cesar de OliveiraSchool of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara, São Paulo 14800-903, Brazil.ORCID 0000-0001-5760-4209
Claudia Tavares Dos SantosSchool of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara, São Paulo 14800-903, Brazil.
Junya de Lacorte SingulaniSchool of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara, São Paulo 14800-903, Brazil.ORCID 0000-0002-7775-0657
Patricia Akemi AssatoSchool of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara, São Paulo 14800-903, Brazil.
Caroline Maria MarcosSchool of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara, São Paulo 14800-903, Brazil.ORCID 0000-0001-9306-7404
Lariane Teodoro OliveiraSchool of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara, São Paulo 14800-903, Brazil.
Nathália Ferreira FregoneziSchool of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara, São Paulo 14800-903, Brazil.
Diego Conrado Pereira RossiDepartment of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-000, Brazil.ORCID 0000-0003-1385-1501
Leandro Buffoni Roque da SilvaDepartment of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-000, Brazil.
Carlos Pelleschi TabordaDepartment of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-000, Brazil.ORCID 0000-0001-9928-9809
Ana Marisa Fusco-AlmeidaSchool of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara, São Paulo 14800-903, Brazil.
Maria José Soares Mendes-GianniniSchool of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara, São Paulo 14800-903, Brazil.
Universidade Estadual Paulista (Unesp) · BRUniversidade de São Paulo · BR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) -Coordenação de Aperfeiçoamento de Pessoal de Nível Superior -Fundação de Amparo à Pesquisa do Estado de São Paulo (LS) 2013/10917-9, (HdO) 2015/14023-8, (CMM) 2016/17048-4, (JLS) 2014/10446-9, (MM-G) 2015/03700-9
6 · The paper itself

Abstract

backgroundParacoccidioidomycosis (PCM) is a chronic disease that causes sequelae and requires prolonged treatment; therefore, new therapeutic approaches are necessary. In view of this, three peptides from

methodsThe in vitro antifungal activity and cytotoxicity of the 14-3-3 peptides were evaluated. The influence of the peptides in immunological and survival aspects was evaluated in vivo, using

resultsNone of the peptides were toxic to HaCaT (skin keratinocyte), MRC-5 (lung fibroblast), and A549 (pneumocyte) cell lines, and only P1 exhibited antifungal activity against

Indexed as

14-3-3 proteinCaenorhabditis elegansGalleria mellonellaParacoccidioides spp.paracoccidioidomycosisvaccine

Identifiers

PMID33451062
PMCPMC7828505
OpenAlexW3119601645

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.