Evidence map›Paper›PMID 33451055›Full record

ReviewInternational journal of molecular sciences2021

Novel Tyrosine Kinase Targets in Urothelial Carcinoma.

Javier Torres-Jiménez, Víctor Albarrán-Fernández, Javier Pozas, María San Román-Gil, Jorge Esteban-Villarrubia, Alfredo Carrato, Adriana Rosero, Enrique Grande, Teresa Alonso-Gordoa, Javier Molina-Cerrillo

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Review
  3. COSMIC-021 Phase Ib Study of Cabozantinib Plus Atezolizumab: Results from the Locally Advanced or Metastatic Urothelial Carcinoma Cohorts.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2025
    Article
  4. Article
  5. Review
  6. Review
  7. Recent Advances in Kinase Drug Discovery Part I: The Editors' Take.International journal of molecular sciences · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Javier Torres-JiménezMedical Oncology Department, University Hospital Ramon y Cajal, 28034 Madrid, Spain.ORCID 0000-0001-9023-4529
Víctor Albarrán-FernándezMedical Oncology Department, University Hospital Ramon y Cajal, 28034 Madrid, Spain.ORCID 0000-0001-6356-2551
Javier PozasMedical Oncology Department, University Hospital Ramon y Cajal, 28034 Madrid, Spain.
María San Román-GilMedical Oncology Department, University Hospital Ramon y Cajal, 28034 Madrid, Spain.ORCID 0000-0002-8810-6525
Jorge Esteban-VillarrubiaMedical Oncology Department, University Hospital Ramon y Cajal, 28034 Madrid, Spain.
Alfredo CarratoMedical Oncology Department, Ramón y Cajal Health Research Institute (IRYCIS), CIBERONC, Alcalá University, University Hospital Ramon y Cajal, 28034 Madrid, Spain.ORCID 0000-0001-7749-8140
Adriana RoseroMedical Oncology Department, Infanta Cristina Hospital, 28607 Madrid, Spain.ORCID 0000-0002-5144-0757
Enrique GrandeDepartment of Medical Oncology, MD Anderson Cancer Center, 28033 Madrid, Spain.
Teresa Alonso-GordoaMedical Oncology Department, Ramón y Cajal Health Research Institute (IRYCIS), CIBERONC, Alcalá University, University Hospital Ramon y Cajal, 28034 Madrid, Spain.ORCID 0000-0002-8966-7236
Javier Molina-CerrilloMedical Oncology Department, Ramón y Cajal Health Research Institute (IRYCIS), CIBERONC, Alcalá University, University Hospital Ramon y Cajal, 28034 Madrid, Spain.ORCID 0000-0003-4616-0598
Hospital Universitario Ramón y Cajal · ESInstituto Cajal · ESHospital Universitario Infanta Cristina · ESMD Anderson Cancer Center Madrid · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Urothelial carcinoma represents one of the most prevalent types of cancer worldwide, and its incidence is expected to grow. Although the treatment of the advanced disease was based on chemotherapy for decades, the developments of different therapies, such as immune checkpoint inhibitors, antibody drug conjugates and tyrosine kinase inhibitors, are revolutionizing the therapeutic landscape of this tumor. This development coincides with the increasing knowledge of the pathogenesis and genetic alterations in urothelial carcinoma, from the non-muscle invasive setting to the metastatic one. The purpose of this article is to provide a comprehensive review of the different tyrosine kinase targets and their roles in the therapeutic scene of urothelial carcinoma.

Indexed as

Biomarkers, TumorMolecular Targeted TherapyAngiogenesis InhibitorsClinical Trials as TopicErbB ReceptorsHumansNeoplasm InvasivenessNeoplasm StagingPhosphatidylinositol 3-KinasesProtein Kinase InhibitorsProtein-Tyrosine KinasesProto-Oncogene Proteins c-aktSignal TransductionTOR Serine-Threonine KinasesTreatment OutcomeUrinary Bladder NeoplasmsAngiogenesis InhibitorsBiomarkers, TumorEGFR protein, humanErbB ReceptorsPhosphatidylinositol 3-KinasesProtein Kinase InhibitorsProtein-Tyrosine KinasesProto-Oncogene Proteins c-aktTOR Serine-Threonine Kinasestyrosine kinasetyrosine kinase inhibitorsurothelial carcinoma

Identifiers

PMID33451055
PMCPMC7828553
OpenAlexW3120797790

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.