Evidence map›Paper›PMID 33451032›Full record

ArticleNanomaterials (Basel, Switzerland)2021

Novel Regeneration Approach for Creating Reusable FO-SPR Probes with NTA Surface Chemistry.

Jia-Huan Qu, Karen Leirs, Remei Escudero, Žiga Strmšek, Roman Jerala, Dragana Spasic, Jeroen Lammertyn

Open access · goldAbstract read
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

  1. Quantitative Detection ofBiosensors · 2025
    Article
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  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Jia-Huan QuBiosensors Group, Department of Biosystems, KU Leuven, Willem de Croylaan 42, 3001 Leuven, Belgium.ORCID 0000-0001-6041-7500
Karen LeirsBiosensors Group, Department of Biosystems, KU Leuven, Willem de Croylaan 42, 3001 Leuven, Belgium.
Remei EscuderoBiosensors Group, Department of Biosystems, KU Leuven, Willem de Croylaan 42, 3001 Leuven, Belgium.
Žiga StrmšekDepartment of Synthetic Biology and Immunology, National Institute of Chemistry, 1000 Ljubljana, Slovenia.
Roman JeralaDepartment of Synthetic Biology and Immunology, National Institute of Chemistry, 1000 Ljubljana, Slovenia.
Dragana SpasicBiosensors Group, Department of Biosystems, KU Leuven, Willem de Croylaan 42, 3001 Leuven, Belgium.
Jeroen LammertynBiosensors Group, Department of Biosystems, KU Leuven, Willem de Croylaan 42, 3001 Leuven, Belgium.ORCID 0000-0001-8143-6794
KU Leuven · BENational Institute of Chemistry · SI

Funding

FWO SBO/S006319NKom op tegen Kanker Stand up to Cancer, the Flemish cancer society
6 · The paper itself

Abstract

To date, surface plasmon resonance (SPR) biosensors have been exploited in numerous different contexts while continuously pushing boundaries in terms of improved sensitivity, specificity, portability and reusability. The latter has attracted attention as a viable alternative to disposable biosensors, also offering prospects for rapid screening of biomolecules or biomolecular interactions. In this context here, we developed an approach to successfully regenerate a fiber-optic (FO)-SPR surface when utilizing cobalt (II)-nitrilotriacetic acid (NTA) surface chemistry. To achieve this, we tested multiple regeneration conditions that can disrupt the NTA chelate on a surface fully saturated with His

Indexed as

antibody fragmentbiosensorfiber-optic-surface plasmon resonance (FO-SPR)His-tagNTA chemistryprotein origami (Tet12SN-RRRR)red fluorescent protein (RFP)SARS-CoV-2 receptor-binding domain (RBD)surface regeneration

Identifiers

PMID33451032
PMCPMC7828519
OpenAlexW3119252329

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.