Evidence map›Paper›PMID 33450964›Full record

ArticleInternational journal of molecular sciences2021

Differential DNA Methylation in Prostate Tumors from Puerto Rican Men.

Gilberto Ruiz-Deya, Jaime Matta, Jarline Encarnación-Medina, Carmen Ortiz-Sanchéz, Julie Dutil, Ryan Putney, Anders Berglund, Jasreman Dhillon, Youngchul Kim, Jong Y Park

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Gilberto Ruiz-DeyaDepartment of Basic Sciences, Ponce Research Institute, Ponce Health Sciences University-School of Medicine, Ponce 00716-2347, Puerto Rico.
Jaime MattaDepartment of Basic Sciences, Ponce Research Institute, Ponce Health Sciences University-School of Medicine, Ponce 00716-2347, Puerto Rico.ORCID 0000-0001-6668-9021
Jarline Encarnación-MedinaDepartment of Basic Sciences, Ponce Research Institute, Ponce Health Sciences University-School of Medicine, Ponce 00716-2347, Puerto Rico.ORCID 0000-0002-0354-6274
Carmen Ortiz-SanchézDepartment of Basic Sciences, Ponce Research Institute, Ponce Health Sciences University-School of Medicine, Ponce 00716-2347, Puerto Rico.ORCID 0000-0003-3567-7866
Julie DutilDepartment of Basic Sciences, Ponce Research Institute, Ponce Health Sciences University-School of Medicine, Ponce 00716-2347, Puerto Rico.
Ryan PutneyDepartment of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA.
Anders BerglundDepartment of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA.ORCID 0000-0002-0393-3530
Jasreman DhillonDepartment of Pathology, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA.
Youngchul KimDepartment of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA.
Jong Y ParkDepartment of Cancer Epidemiology, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA.
Moffitt Cancer Center · USPonce Health Sciences University · PR

Funding

Using MC1R genotype to impact skin cancer risk behaviors in Hispanics/LatinosU54CA163068 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI KENNETH Lynn WRIGHT · 2012 to 2026
$23.1M
Using MC1R genotype to impact skin cancer risk behaviors in Hispanics/LatinosU54CA163071 · NCI · PONCE SCHOOL OF MEDICINE · PI Luisa Morales-Torres · 2012 to 2026
$23.0M
NCI NIH HHS U54 CA163068NCI NIH HHS U54 CA163071<span style="color:gray;font-size:10px;">United States</span> U54 CA163068-07
6 · The paper itself

Abstract

In 2020, approximately 191,930 new prostate cancer (PCa) cases are estimated in the United States (US). Hispanic/Latinos (H/L) are the second largest racial/ethnic group in the US. This study aims to assess methylation patterns between aggressive and indolent PCa including DNA repair genes along with ancestry proportions. Prostate tumors classified as aggressive (

Indexed as

DNA MethylationEpigenesis, GeneticAgedCpG IslandsDisease ProgressionDNA RepairGene Expression ProfilingGene Expression Regulation, NeoplasticHumansMaleMiddle AgedNeoplasm GradingNeoplasm StagingProstatic NeoplasmsPuerto Ricoaggressive prostate cancerancestryDNA methylationDNA repairGleason scoreHispanic/Latinoindolent prostate cancerprostate cancer

Identifiers

PMID33450964
PMCPMC7828429
OpenAlexW3120438164

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.