Evidence map›Paper›PMID 33450922›Full record

ArticleCancers2021

Aberrant Dyskerin Expression Is Related to Proliferation and Poor Survival in Endometrial Cancer.

Rafah Alnafakh, Gabriele Saretzki, Angela Midgley, James Flynn, Areege M Kamal, Lucy Dobson, Purushothaman Natarajan, Helen Stringfellow, Pierre Martin-Hirsch, Shandya B DeCruze and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 32 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Rafah AlnafakhLiverpool Women's Hospital NHS Foundation Trust, Member of Liverpool Health Partners, Liverpool L8 7SS, UK.
Gabriele SaretzkiBiosciences Institute, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne NE4 5PL, UK.ORCID 0000-0003-2100-8223
Angela MidgleyExperimental Arthritis Treatment Centre for Children, Institute in the Park, Department of Women's and Children's Health, University of Liverpool, Liverpool L12 2AP, UK.
James FlynnIllumina Inc., San Diego, CA 92122, USA.
Areege M KamalDepartment of Women's and Children's Health, Institute of Life Course and Medical Sciences, University of Liverpool, Member of Liverpool Health Partners, Liverpool L8 7SS, UK.
Lucy DobsonLiverpool Women's Hospital NHS Foundation Trust, Member of Liverpool Health Partners, Liverpool L8 7SS, UK.
Purushothaman NatarajanLiverpool Women's Hospital NHS Foundation Trust, Member of Liverpool Health Partners, Liverpool L8 7SS, UK.
Helen StringfellowLancashire Teaching Hospital NHS Trust, Preston PR2 9HT, UK.
Pierre Martin-HirschLancashire Teaching Hospital NHS Trust, Preston PR2 9HT, UK.
Shandya B DeCruzeLiverpool Women's Hospital NHS Foundation Trust, Member of Liverpool Health Partners, Liverpool L8 7SS, UK.
Sarah E CouplandMolecular and Clinical Cancer Medicine, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool L7 8TX, UK.ORCID 0000-0002-1464-2069
Dharani K HapangamaLiverpool Women's Hospital NHS Foundation Trust, Member of Liverpool Health Partners, Liverpool L8 7SS, UK.ORCID 0000-0003-0270-0150
University of Liverpool · GBLancashire Teaching Hospitals NHS Foundation Trust · GBIllumina (United States) · USNewcastle Hospitals - Campus for Ageing and Vitality · GB

Funding

Higher Committee for Education Development in Iraq RA and AK PhD studentshipsWellbeing of Women RG1487 and RG2137
6 · The paper itself

Abstract

Dyskerin is a core-component of the telomerase holo-enzyme, which elongates telomeres. Telomerase is involved in endometrial epithelial cell proliferation. Most endometrial cancers (ECs) have high telomerase activity; however, dyskerin expression in human healthy endometrium or in endometrial pathologies has not been investigated yet. We aimed to examine the expression, prognostic relevance, and functional role of dyskerin in human EC. Endometrial samples from a cohort of 175 women were examined with immunohistochemistry, immunoblotting, and qPCR. The EC cells were transfected with Myc-DDK-DKC1 plasmid and the effect of dyskerin overexpression on EC cell proliferation was assessed by flow cytometry. Human endometrium expresses dyskerin (

Indexed as

DKC1dyskerinendometrial cancerproliferationtelomerasetelomeres

Identifiers

PMID33450922
PMCPMC7828388
OpenAlexW3120705480

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.