Evidence map›Paper›PMID 33450879›Full record

ArticleCancers2021

Lysine Deprivation Induces AKT-AADAT Signaling and Overcomes EGFR-TKIs Resistance in

Chia-Chi Hsu, Albert Ying-Po Yang, Jui-Yi Chen, Hsin-Hui Tsai, Shu-Heng Lin, Pei-Chen Tai, Ming-Hung Huang, Wei-Hsun Hsu, Anya Maan-Yuh Lin, James Chih-Hsin Yang

Open access · goldAbstract read

PubMed Full text at PMC Publisher

In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it

0cells of the map it votes in

6citing papers in PubMed

1.5field-weighted citation impact, top 18% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

SUMOylation activates ECHS1 for adaptive catabolism in lung cancer.Cell death & disease · 2026
Article
Lysine-arginine imbalance overcomes therapeutic tolerance governed by the transcription factor E3-lysosome axis in glioblastoma.Nature communications · 2025
Article
Genome wide interaction study of genetic variants associated with lung function decline.Scientific reports · 2025
Article
Crosstalk between Metabolite Production and Signaling Activity in Breast Cancer.International journal of molecular sciences · 2023
Article
Proline metabolism reprogramming of trained macrophages induced by early respiratory infection combined with allergen sensitization contributes to development of allergic asthma in childhood of mice.Frontiers in immunology · 2022
Article
L-Lysine α-Oxidase: Enzyme with Anticancer Properties.Pharmaceuticals (Basel, Switzerland) · 2021
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Chia-Chi HsuGraduate Institute of Oncology, College of Medicine, National Taiwan University, Taipei 100, Taiwan.ORCID 0000-0003-1532-7017

Albert Ying-Po YangGraduate Institute of Oncology, College of Medicine, National Taiwan University, Taipei 100, Taiwan.ORCID 0000-0002-3576-9157

Jui-Yi ChenGraduate Institute of Oncology, College of Medicine, National Taiwan University, Taipei 100, Taiwan.

Hsin-Hui TsaiGraduate Institute of Oncology, College of Medicine, National Taiwan University, Taipei 100, Taiwan.

Shu-Heng LinGraduate Institute of Oncology, College of Medicine, National Taiwan University, Taipei 100, Taiwan.

Pei-Chen TaiGraduate Institute of Oncology, College of Medicine, National Taiwan University, Taipei 100, Taiwan.

Ming-Hung HuangGraduate Institute of Oncology, College of Medicine, National Taiwan University, Taipei 100, Taiwan.

Wei-Hsun HsuGraduate Institute of Oncology, College of Medicine, National Taiwan University, Taipei 100, Taiwan.

Anya Maan-Yuh LinFaculty of Pharmacy, National Yang-Ming University, Taipei 112, Taiwan.

James Chih-Hsin YangGraduate Institute of Oncology, College of Medicine, National Taiwan University, Taipei 100, Taiwan.

National Taiwan University · TWNational Yang Ming Chiao Tung University · TW

Funding

Ministry of Education, Taiwan NTU-108L901403Ministry of Education, Taiwan NTU-109L901403Ministry of Science & Technology, Taiwan 107-2314-B-002-220-MY3Ministry of Science & Technology, Taiwan 108-2811-B-002-568Ministry of Science & Technology, Taiwan 109-2634-F-002-043

6 · The paper itself

Abstract

Epidermal growth factor receptor (

Indexed as

AADATEGFR-mutant NSCLCEGFR-TKI resistancelysine deprivationosimertinib

Identifiers

PMID33450879

DOI10.3390/cancers13020272

PMCPMC7828377

OpenAlexW3119725146

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.