Evidence map›Paper›PMID 33450872›Full record

ArticleInternational journal of molecular sciences2021

Expression Levels of an Alpha-Synuclein Transcript in Blood May Distinguish between Early Dementia with Lewy Bodies and Parkinson's Disease.

Laura Marsal-García, Aintzane Urbizu, Laura Arnaldo, Jaume Campdelacreu, Dolores Vilas, Lourdes Ispierto, Jordi Gascón-Bayarri, Ramón Reñé, Ramiro Álvarez, Katrin Beyer

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Age-Specific Clinical Biomarker Ranges in Acute Head Injury, Non-TBI Trauma, and Healthy Control Subjects in the Emergency Department.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2026
    Article
  2. Review
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  5. The Impact ofLife (Basel, Switzerland) · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Laura Marsal-GarcíaDepartment of Pathology, Germans Trias i Pujol Research Institute (IGTP), Universitat Autònoma de Barcelona (UAB), 08193 Barcelona, Spain.ORCID 0000-0002-6337-1656
Aintzane UrbizuDepartment of Pathology, Germans Trias i Pujol Research Institute (IGTP), Universitat Autònoma de Barcelona (UAB), 08193 Barcelona, Spain.ORCID 0000-0001-8458-1209
Laura ArnaldoDepartment of Pathology, Germans Trias i Pujol Research Institute (IGTP), Universitat Autònoma de Barcelona (UAB), 08193 Barcelona, Spain.ORCID 0000-0003-1654-0573
Jaume CampdelacreuServei de Neurologia, Hospital Universitari Bellvitge, 08907 L'Hospitalet de Llobregat, Spain.
Dolores VilasServei de Neurologia, Hospital Universitari Germans Trias i Pujol, 08916 Badalona, Spain.ORCID 0000-0003-3084-053X
Lourdes IspiertoServei de Neurologia, Hospital Universitari Germans Trias i Pujol, 08916 Badalona, Spain.
Jordi Gascón-BayarriServei de Neurologia, Hospital Universitari Bellvitge, 08907 L'Hospitalet de Llobregat, Spain.ORCID 0000-0002-9422-937X
Ramón ReñéServei de Neurologia, Hospital Universitari Bellvitge, 08907 L'Hospitalet de Llobregat, Spain.
Ramiro ÁlvarezServei de Neurologia, Hospital Universitari Germans Trias i Pujol, 08916 Badalona, Spain.
Katrin BeyerDepartment of Pathology, Germans Trias i Pujol Research Institute (IGTP), Universitat Autònoma de Barcelona (UAB), 08193 Barcelona, Spain.ORCID 0000-0001-8905-1514
Universitat Autònoma de Barcelona · ESBellvitge University Hospital · ESHospital Universitari Germans Trias i Pujol · ES

Funding

Ministerio de Ciencia e Innovación PI18/00276, PI15/00216
6 · The paper itself

Abstract

Lewy body diseases (LBD) including dementia with Lewy bodies (DLB) and Parkinson disease (PD) are characterized by alpha-synuclein pathology. DLB is difficult to diagnose and peripheral biomarkers are urgently needed. Therefore, we analyzed the expression of five alpha-synuclein gene (

Indexed as

Gene ExpressionAgedAged, 80 and overalpha-SynucleinBiomarkersBrainDementiaDisease ProgressionFemaleHumansLewy BodiesMaleMiddle AgedParkinson DiseaseSeverity of Illness Indexalpha-SynucleinBiomarkersalpha-synucleindementia with Lewy bodiesdifferential mRNA transcript expressiondisease progressionParkinson’s diseaseperipheral biomarkerSNCA transcript variants

Identifiers

PMID33450872
PMCPMC7828374
OpenAlexW3120266887

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.