Evidence map›Paper›PMID 33450834›Full record

ArticleInternational journal of molecular sciences2021

Harper Smith, Nick Pinkerton, David B Heisler, Elena Kudryashova, Aaron R Hall, Kelly R Karch, Andrew Norris, Vicki Wysocki, Marcos Sotomayor, Emil Reisler and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Harper SmithDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA.
Nick PinkertonDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA.
David B HeislerDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0002-6482-4215
Elena KudryashovaDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0002-1646-1229
Aaron R HallDepartment of Physics, Lehigh University, Bethlehem, PA 18015, USA.
Kelly R KarchDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0002-6350-3217
Andrew NorrisDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0002-0121-5922
Vicki WysockiDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA.
Marcos SotomayorDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA.
Emil ReislerDepartment of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095, USA.
Dimitrios VavylonisDepartment of Physics, Lehigh University, Bethlehem, PA 18015, USA.ORCID 0000-0003-1802-3262
Dmitri S KudryashovDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0003-1782-3305
The Ohio State University · USLehigh University · USUniversity of California, Los Angeles · US

Funding

Waters Select Series Cyclic IMS for P41 Native MS Resource Application to Alzheimer's DiseaseP41GM128577 · NIGMS · OHIO STATE UNIVERSITY · PI WYSOCKI, VICKI H. · 2018 to 2022
$7.6M
Dynamic Events in Myosin and Actin and Their FunctionR01GM077190 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI REISLER, EMIL · 2006 to 2020
$6.2M
Name Molecular mechanisms of bacterial toxins targeting actin cytoskeletonR01GM114666 · NIGMS · OHIO STATE UNIVERSITY · PI KUDRYASHOV, DMITRI · 2015 to 2025
$3.8M
Modeling mechanisms in cytokinesis, cell polarization and motilityR35GM136372 · NIGMS · LEHIGH UNIVERSITY · PI Dimitrios Vavylonis · 2020 to 2026
$3.2M
NIGMS NIH HHS P41 GM128577NIGMS NIH HHS R01 GM077190NIGMS NIH HHS R01 GM114666NIGMS NIH HHS R01 GM114666, R01 GM077190, R35 GM136372NIGMS NIH HHS R35 GM136372
6 · The paper itself

Abstract

Actin is an essential element of both innate and adaptive immune systems and can aid in motility and translocation of bacterial pathogens, making it an attractive target for bacterial toxins. Pathogenic

Indexed as

Protein MultimerizationActin CytoskeletonActinsAnimalsBacterial ToxinsBinding SitesCatalysisCell Line, TumorConserved SequenceHumansKineticsModels, MolecularProtein BindingProtein ConformationVibrio choleraeActinsBacterial ToxinsACDactinactin cross-linking domainbacterial toxinsEna/VASPforminisopeptide bondMARTXmass spectrometrymolecular dynamicsmultivalent interactionspolymerization

Identifiers

PMID33450834
PMCPMC7828245
OpenAlexW3119899456

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.