Evidence map›Paper›PMID 33450666›Full record

ArticleAddictive behaviors2021

Gender and past year serious psychological distress are associated with past year AUD: Time-varying results from the National Survey on Drug Use and Health (NSDUH; 2008-2017).

Terril L Verplaetse, MacKenzie R Peltier, Walter Roberts, Brian Pittman, Sherry A McKee

Open access · greenAbstract read
In one paragraph

Article in Addictive behaviors, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Terril L VerplaetseDepartment of Psychiatry, Yale School of Medicine, New Haven, CT 06519, United States. Electronic address: terril.verplaetse@yale.edu.
MacKenzie R PeltierDepartment of Psychiatry, Yale School of Medicine, New Haven, CT 06519, United States.
Walter RobertsDepartment of Psychiatry, Yale School of Medicine, New Haven, CT 06519, United States.
Brian PittmanDepartment of Psychiatry, Yale School of Medicine, New Haven, CT 06519, United States.
Sherry A McKeeDepartment of Psychiatry, Yale School of Medicine, New Haven, CT 06519, United States.
Yale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Yale-SCORE Resource Support CoreU54AA027989 · NIAAA · YALE UNIVERSITY · PI Ralitza Gueorguieva · 2020 to 2026
$13.0M
Sex-Appropriate Treatment Development for Alcohol Use DisordersP01AA027473 · NIAAA · YALE UNIVERSITY · PI MCKEE, SHERRY ANN · 2018 to 2019
$1.0M
Behavioral and Neurochemical Mechanisms Underlying Stress-Precipitated DrinkingK01AA025670 · NIAAA · YALE UNIVERSITY · PI VERPLAETSE, TERRIL L · 2018 to 2023
$882k
Developing a mobile alcohol biosensor platform for use in medication testing researchK23AA026890 · NIAAA · YALE UNIVERSITY · PI ROBERTS, WALTER MCRAINEY · 2019 to 2023
$827k
Does endotoxin administration increase alcohol consumption in individuals with AUD?R03AA028361 · NIAAA · YALE UNIVERSITY · PI VERPLAETSE, TERRIL L · 2021 to 2022
$168k
NCATS NIH HHS UL1 TR001863NIAAA NIH HHS K01 AA025670NIAAA NIH HHS K23 AA026890NIAAA NIH HHS P01 AA027473NIAAA NIH HHS R03 AA028361NIAAA NIH HHS U54 AA027989
6 · The paper itself

Abstract

backgroundRates of alcohol use disorder (AUD) have increased in women in the last decade. Women may be more likely to engage in alcohol use to regulate stress and negative affect compared to men. Findings from our group found that life event stress was more strongly associated with new AUD in women vs. men. Our aim was to extend these findings to psychological distress, a potentially related construct to stress, using a second nationally representative dataset.

methodsUsing data from the National Survey on Drug Use and Health (NSDUH; 2008-2017, total n = 562,072), we examined time-varying associations between gender and past year serious psychological distress (SPD; Kessler-6 distress scale: scores > 13 yes, <13 no) with past year vs. absent DSM-IV AUD.

resultsA significant (p < 0.0001) gender by SPD interaction for past year vs. absent AUD demonstrated that past year SPD was associated with increased odds of past year AUD in men (OR = 3.33, 95% CI = 3.15, 3.52) and even greater odds of past year AUD in women (OR = 4.39, 95% CI = 4.14, 4.66). The gender by SPD by time interaction was not significant (p = 0.06).

conclusionsResults highlight that while men with past year SPD were 3 times more likely to have a past year AUD, women with past year SPD were nearly 4.5 times more likely to have a past year AUD. Psychological distress is clearly an important factor in AUD in both men and women, but results suggest that other factors may be driving the increase in rates of AUD in women.

Indexed as

AlcoholismPharmaceutical PreparationsPsychological DistressFemaleHealth SurveysHumansMalePrevalenceStress, PsychologicalPharmaceutical PreparationsAlcoholAlcohol use disorderDistressGenderSex

Identifiers

PMID33450666
PMCPMC7887085
OpenAlexW3119405660

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.