ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2021
Four-dimensional tractography animates propagations of neural activation via distinct interhemispheric pathways.
Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Naming-related spectral responses predict neuropsychological outcome after epilepsy surgery.Brain : a journal of neurology · 2022Trial
- Effective connectivity between homologous cortices mediated by the corpus callosum: An axono-cortical evoked potentials study.Clinical neurophysiology practice · 2026Article
- Article
- Dynamic Causal Tractography Analysis of Auditory Descriptive Naming: An Intracranial Study of 106 Patients.NeuroImage · 2025Article
- Article
- Network excitability of stimulation-induced spectral responses helps localize the seizure onset zone.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2024Article
- Article
- Bipolar and Laplacian montages are suitable for high-gamma modulation language mapping with stereoelectroencephalography.Frontiers in neurology · 2024Article
- Dynamic cortical and tractography atlases of proactive and reactive alpha and high-gamma activities.Brain communications · 2023Article
- Six-dimensional dynamic tractography atlas of language connectivity in the developing brain.Brain : a journal of neurology · 2021Article
- Dynamic tractography-based localization of spike sources and animation of spike propagations.Epilepsia · 2021Article
- Your verbal questions beginning with 'what' will rapidly deactivate the left prefrontal cortex of listeners.Scientific reports · 2021Article
- Intraoperative Brain Mapping by Cortico-Cortical Evoked Potential.Frontiers in human neuroscience · 2021Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
objectiveTo visualize and validate the dynamics of interhemispheric neural propagations induced by single-pulse electrical stimulation (SPES).
methodsThis methodological study included three patients with drug-resistant focal epilepsy who underwent measurement of cortico-cortical spectral responses (CCSRs) during bilateral stereo-electroencephalography recording. We delivered SPES to 83 electrode pairs and analyzed CCSRs recorded at 268 nonepileptic electrode sites. Diffusion-weighted imaging (DWI) tractography localized the interhemispheric white matter pathways as streamlines directly connecting two electrode sites. We localized and visualized the putative SPES-related fiber activation, at each 1-ms time window, based on the propagation velocity defined as the DWI-based streamline length divided by the early CCSR peak latency.
resultsThe resulting movie, herein referred to as four-dimensional tractography, delineated the spatiotemporal dynamics of fiber activation via the corpus callosum and anterior commissure. Longer streamline length was associated with delayed peak latency and smaller amplitude of CCSRs. The cortical regions adjacent to each fiber activation site indeed exhibited CCSRs at the same time window.
conclusionsOur four-dimensional tractography successfully animated neural propagations via distinct interhemispheric pathways. SIGNIFICANCE: Our novel animation method has the potential to help investigators in addressing the mechanistic significance of the interhemispheric network dynamics supporting physiological function.
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