Evidence map›Paper›PMID 33450531›Full record

ReviewDiabetes & metabolic syndrome

Blood glucose levels should be considered as a new vital sign indicative of prognosis during hospitalization.

Jothydev Kesavadev, Anoop Misra, Banshi Saboo, S R Aravind, Akhtar Hussain, Leszek Czupryniak, Itamar Raz

Erratum issuedOpen access · greenAbstract readReview
In one paragraph

Review in Diabetes & metabolic syndrome. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 43 citations in OpenAlex.

  1. Article
  2. Accuracy of continuous glucose monitoring in critically ill patients.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2025
    Article
  3. Observational
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  14. Evaluation of Antidiabetic Activity of Oxadiazole Derivative in Rats.Evidence-based complementary and alternative medicine : eCAM · 2023
    Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Using the Major Components (Cellulose, Hemicellulose, and Lignin) ofFrontiers in bioengineering and biotechnology · 2021
    Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 4 countries.

Jothydev KesavadevJothydev's Diabetes Research Centers, Kerala, India. Electronic address: jothydev@gmail.com.
Anoop MisraFortis-C-DOC Centre of Excellence for Diabetes, Metabolic Diseases and Endocrinology, India; National Diabetes, Obesity and Cholesterol Foundation (N-DOC), India; Diabetes Foundation (India) (DFI), India. Electronic address: anoopmisra@gmail.com.
Banshi SabooDiacare, Diabetes Care & Hormone Clinic, Ahmedabad, India. Electronic address: banshisaboo98@gmail.com.
S R AravindDiacon Hospital, Bangalore, India. Electronic address: draravind@hotmail.com.
Akhtar HussainFaculty of Health Sciences, Chronic Disease-Diabetes, NORD University, Stjørdal, Norway; Faculty of Medicine, Federal University of Ceara, Brazil. Electronic address: hussain.akhtar@nord.no.
Leszek CzupryniakMedical University of Warsaw, Department of Diabetology and Internal Medicine, Warsaw, Poland. Electronic address: leszek.czupryniak@wum.edu.pl.
Itamar RazInternal Medicine, and Head of the Diabetes Unit at Hadassah University Hospital, Israel. Electronic address: razitamar502@gmail.com.
Diabetes Care & Hormone Clinic · INDiabetes Foundation · INDiacon Hospital · INJothydev's Diabetes and Research Center · INMedical University of Warsaw · PLNord University · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsThe measurement of vital signs is an important part of clinical work up. Presently, measurement of blood glucose is a factor for concern mostly when treating individuals with diabetes. Significance of blood glucose measurement in prognosis of non-diabetic and hospitalized patients is not clear.

methodsA systematic search of literature published in the Electronic databases, PubMed and Google Scholar was performed using following keywords; blood glucose, hospital admissions, critical illness, hospitalizations, cardiovascular disease (CVD), morbidity, and mortality. This literature search was largely restricted to non-diabetic individuals.

resultsBlood glucose level, even when in high normal range, or in slightly high range, is an important determinant of morbidity and mortality, especially in hospitalized patients. Further, even slight elevation of blood glucose may increase mortality in patients with COVID-19. Finally, blood glucose variability and hypoglycemia in critically ill individuals without diabetes causes excess in-hospital complications and mortality.

conclusionIn view of these data, we emphasize the significance of blood glucose measurement in all patients admitted to the hospital regardless of presence of diabetes. We propose that blood glucose be included as the "fifth vital sign" for any hospitalized patient.

Indexed as

Blood GlucoseCOVID-19Critical IllnessDiabetes MellitusHospitalizationHumansHyperglycemiaHypoglycemiaPrognosisVital SignsBlood GlucoseBlood glucoseCardiovascular diseaseGlycemic variabilityHypoglycemiaImpaired glucose toleranceIntensive insulin therapy

Identifiers

PMID33450531
PMCPMC8049470
OpenAlexW3118760995

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.