Evidence map›Paper›PMID 33450375›Full record

ArticleFree radical biology & medicine2021

Oxygen sensing, mitochondrial biology and experimental therapeutics for pulmonary hypertension and cancer.

Danchen Wu, Asish Dasgupta, Austin D Read, Rachel E T Bentley, Mehras Motamed, Kuang-Hueih Chen, Ruaa Al-Qazazi, Jeffrey D Mewburn, Kimberly J Dunham-Snary, Elahe Alizadeh and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Free radical biology & medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
3.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 60 citations in OpenAlex.

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  14. Metabolic theory of preeclampsia: implications for maternal cardiovascular health.American journal of physiology. Heart and circulatory physiology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Danchen WuDepartment of Medicine, Queen's University, 94 Stuart St., Kingston, Ontario, K7L 3N6, Canada.
Asish DasguptaDepartment of Medicine, Queen's University, 94 Stuart St., Kingston, Ontario, K7L 3N6, Canada.
Austin D ReadDepartment of Medicine, Queen's University, 94 Stuart St., Kingston, Ontario, K7L 3N6, Canada.
Rachel E T BentleyDepartment of Medicine, Queen's University, 94 Stuart St., Kingston, Ontario, K7L 3N6, Canada.
Mehras MotamedDepartment of Medicine, Queen's University, 94 Stuart St., Kingston, Ontario, K7L 3N6, Canada.
Kuang-Hueih ChenDepartment of Medicine, Queen's University, 94 Stuart St., Kingston, Ontario, K7L 3N6, Canada.
Ruaa Al-QazaziDepartment of Medicine, Queen's University, 94 Stuart St., Kingston, Ontario, K7L 3N6, Canada.
Jeffrey D MewburnDepartment of Medicine, Queen's University, 94 Stuart St., Kingston, Ontario, K7L 3N6, Canada.
Kimberly J Dunham-SnaryDepartment of Medicine, Queen's University, 94 Stuart St., Kingston, Ontario, K7L 3N6, Canada; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, K7L 3N6, Canada.
Elahe AlizadehQueen's Cardiopulmonary Unit (QCPU), Department of Medicine, Queen's University, 116 Barrie Street, Kingston, ON, K7L 3J9, Canada.
Lian TianStrathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, G4 0RE, UK.
Stephen L ArcherDepartment of Medicine, Queen's University, 94 Stuart St., Kingston, Ontario, K7L 3N6, Canada. Electronic address: stephen.archer@queensu.ca.
Queen's University · CAUniversity of Strathclyde · GB

Funding

O2 sensing in the human and rabbit ductus arteriosus.R01HL071115 · NHLBI · UNIVERSITY OF CHICAGO · PI ARCHER, STEPHEN L · 2004 to 2015
$3.1M
The Role of DRP-1 and Mitochondrial Fission in Pulmonary Arterial HypertensionR01HL113003 · NHLBI · QUEEN'S UNIVERSITY AT KINGSTON · PI ARCHER, STEPHEN L · 2013 to 2016
$1.1M
Impaired mitochondrial fusion in pulmonary arterial hypertensionRC1HL099462 · NHLBI · UNIVERSITY OF CHICAGO · PI ARCHER, STEPHEN L · 2009 to 2010
$1.0M
NHLBI NIH HHS R01 HL071115NHLBI NIH HHS R01 HL113003NHLBI NIH HHS RC1 HL099462
6 · The paper itself

Abstract

The homeostatic oxygen sensing system (HOSS) optimizes systemic oxygen delivery. Specialized tissues utilize a conserved mitochondrial sensor, often involving NDUFS2 in complex I of the mitochondrial electron transport chain, as a site of pO

Indexed as

Hypertension, PulmonaryNeoplasmsBiologyHumansHydrogen PeroxideOxygenHydrogen PeroxideOxygenABT-199 (Venetoclax)ABT-263 (Navitoclax)B-Cell lymphoma 2 (BCL-2)DNA methylationDNA methyltransferase (DNMT)Dynamin-related protein 1 (Drp1)Group 1 pulmonary hypertensionHypoxia-inducible factor 1α (HIF-1α)Hypoxia-inducible factor 2α (HIF-2α)Hypoxic pulmonary vasoconstrictionMammalian target of rapamycin (mTOR)microRNA (miRNA)miR-138miR-25Mitochondrial calcium uniporter (MCU)Mitochondrial dynamics protein of 49 kDa (MiD49)Mitochondrial dynamics protein of 51 kDa (MiD51)Mitofusin 2 (Mfn2)MitophagyMonocrotalineOxygen sensingPeroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α)Pyruvate dehydrogenase kinase (PDK)Pyruvate dehydrogenase (PDH)Pyruvate kinase muscle isoform 2 (PKM2)Reactive oxygen species (ROS)Sugen5416Survivinvon hippel-lindau protein (VHL)

Identifiers

PMID33450375
PMCPMC8217091
OpenAlexW3118847847

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.