Evidence map›Paper›PMID 33450320›Full record

ArticleJournal of controlled release : official journal of the Controlled Release Society2021

PEGylation enables subcutaneously administered nanoparticles to induce antigen-specific immune tolerance.

Peter Y Li, Frank Bearoff, Pu Zhu, Zhiyuan Fan, Yucheng Zhu, Mingyue Fan, Laura Cort, Taku Kambayashi, Elizabeth P Blankenhorn, Hao Cheng

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of controlled release : official journal of the Controlled Release Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
3.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 62 citations in OpenAlex.

  1. Article
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  3. Article
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  7. Remote loading of an autoantigen in PLGA nanoparticles for the treatment of multiple sclerosis.Journal of controlled release : official journal of the Controlled Release Society · 2025
    Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Review
  13. Review
  14. Review
  15. Emerging strategies for nanomedicine in autoimmunity.Advanced drug delivery reviews · 2024
    Review
  16. Vaccines for immune tolerance against autoimmune disease.Advanced drug delivery reviews · 2023
    Review
  17. Review
  18. Biomaterial Strategies for Selective Immune Tolerance: Advances and Gaps.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Peter Y LiDepartment of Materials Science and Engineering, Drexel University, Philadelphia, PA 19104, USA.
Frank BearoffDepartment of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19129, USA.
Pu ZhuDepartment of Materials Science and Engineering, Drexel University, Philadelphia, PA 19104, USA.
Zhiyuan FanDepartment of Materials Science and Engineering, Drexel University, Philadelphia, PA 19104, USA.
Yucheng ZhuDepartment of Materials Science and Engineering, Drexel University, Philadelphia, PA 19104, USA.
Mingyue FanSchool of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA 19104, USA.
Laura CortDepartment of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19129, USA.
Taku KambayashiDepartment of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
Elizabeth P BlankenhornDepartment of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19129, USA. Electronic address: eb29@drexel.edu.
Hao ChengDepartment of Materials Science and Engineering, Drexel University, Philadelphia, PA 19104, USA; School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA 19104, USA. Electronic address: hcheng@drexel.edu.
Drexel University · USUniversity of Pennsylvania · US

Funding

Injectable Biomaterial Scaffold for Inducing Antigen-Specific ToleranceR21AI133372 · NIAID · DREXEL UNIVERSITY · PI BLANKENHORN, ELIZABETH P, CHENG, HAO · 2017 to 2018
$430k
NIAID NIH HHS R21 AI133372
6 · The paper itself

Abstract

The development of nanomaterials to induce antigen-specific immune tolerance has shown promise for treating autoimmune diseases. While PEGylation has been widely used to reduce host immune responses to nanomaterials, its tolerogenic potential has not been reported. Here, we report for the first time that a subcutaneous injection of PEGylated poly(lactide-co-glycolide) (PLGA) nanoparticles containing auto-antigen peptide MOG

Indexed as

Encephalomyelitis, Autoimmune, ExperimentalMultiple SclerosisNanoparticlesAnimalsAntigensDendritic CellsImmune ToleranceMiceAntigensAnergyBiomaterialsExperimental autoimmune encephalomyelitisImmune cell recruitmentImmunotherapyLocal immune modulation

Identifiers

PMID33450320
PMCPMC7968989
OpenAlexW3119861799

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.