Evidence map›Paper›PMID 33450179›Full record

ArticleCell metabolism2021

MiR-690, an exosomal-derived miRNA from M2-polarized macrophages, improves insulin sensitivity in obese mice.

Wei Ying, Hong Gao, Felipe Castellani Gomes Dos Reis, Gautam Bandyopadhyay, Jachelle M Ofrecio, Zhenlong Luo, Yudong Ji, Zhongmou Jin, Crystal Ly, Jerrold M Olefsky

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 189 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
189citing papers in PubMed, 1 pooled it
18.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

189 citing papers in PubMed, 1 synthesis or guideline pooled it, 288 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Granzyme B PET Imaging Reveals LgmnAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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  7. Metabolic Reprogramming and ILC2 Plasticity in Obesity-related Asthma.Clinical reviews in allergy & immunology · 2026
    Review
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  9. Article
  10. Review
  11. Deregulated miR-487b-3p in Patients with Non-Alcoholic Fatty Liver Disease and Its Regulatory Effect on Insulin Resistance.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2026
    Article
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129 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Wei YingDivision of Endocrinology & Metabolism, Department of Medicine, University of California, San Diego, San Diego, CA, USA. Electronic address: weying@health.ucsd.edu.
Hong GaoDivision of Endocrinology & Metabolism, Department of Medicine, University of California, San Diego, San Diego, CA, USA.
Felipe Castellani Gomes Dos ReisDivision of Endocrinology & Metabolism, Department of Medicine, University of California, San Diego, San Diego, CA, USA.
Gautam BandyopadhyayDivision of Endocrinology & Metabolism, Department of Medicine, University of California, San Diego, San Diego, CA, USA.
Jachelle M OfrecioDivision of Endocrinology & Metabolism, Department of Medicine, University of California, San Diego, San Diego, CA, USA.
Zhenlong LuoDivision of Endocrinology & Metabolism, Department of Medicine, University of California, San Diego, San Diego, CA, USA.
Yudong JiDivision of Endocrinology & Metabolism, Department of Medicine, University of California, San Diego, San Diego, CA, USA.
Zhongmou JinDivision of Biological Sciences, University of California, San Diego, San Diego, CA, USA.
Crystal LyDivision of Biological Sciences, University of California, San Diego, San Diego, CA, USA.
Jerrold M OlefskyDivision of Endocrinology & Metabolism, Department of Medicine, University of California, San Diego, San Diego, CA, USA. Electronic address: jolefsky@health.ucsd.edu.
University of California San Diego · USUC San Diego Health System · US

Funding

Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PETER J TONTONOZ · 2003 to 2026
$40.4M
Effects of Fractalkine on Beta Cell FunctionR01DK101395 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI OLEFSKY, JERROLD MICHAEL · 2014 to 2017
$1.6M
Adipose tissue macrophages secrete exosome-miRs as paracrine/endocrine molecules to directly modulate insulin target cell function in response to obesityR00DK115998 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI YING, WEI · 2020 to 2022
$739k
NIDDK NIH HHS P30 DK063491NIDDK NIH HHS R00 DK115998NIDDK NIH HHS R01 DK101395
6 · The paper itself

Abstract

Insulin resistance is a major pathophysiologic defect in type 2 diabetes and obesity, while anti-inflammatory M2-like macrophages are important in maintaining normal metabolic homeostasis. Here, we show that M2 polarized bone marrow-derived macrophages (BMDMs) secrete miRNA-containing exosomes (Exos), which improve glucose tolerance and insulin sensitivity when given to obese mice. Depletion of their miRNA cargo blocks the ability of M2 BMDM Exos to enhance insulin sensitivity. We found that miR-690 is highly expressed in M2 BMDM Exos and functions as an insulin sensitizer both in vivo and in vitro. Expressing an miR-690 mimic in miRNA-depleted BMDMs generates Exos that recapitulate the effects of M2 BMDM Exos on metabolic phenotypes. Nadk is a bona fide target mRNA of miR-690, and Nadk plays a role in modulating macrophage inflammation and insulin signaling. Taken together, these data suggest miR-690 could be a new therapeutic insulin-sensitizing agent for metabolic disease.

Indexed as

AdipocytesAnimalsAntagomirsDEAD-box RNA HelicasesDiet, High-FatExosomesHepatocytesInsulinInsulin ResistanceMacrophagesMiceMice, Inbred C57BLMice, KnockoutMice, ObeseMicroRNAsMuscle Fibers, SkeletalAntagomirsDEAD-box RNA HelicasesDicer1 protein, mouseInsulinMicroRNAsMIRN690 microRNA, mouseNAD kinasePhosphotransferases (Alcohol Group Acceptor)Ribonuclease IIIRNA, Small Interferingexosomesinsulin sensitivitymacrophagesmiR-690obesity

Identifiers

PMID33450179
PMCPMC8035248
OpenAlexW3120374468

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.