Evidence map›Paper›PMID 33450159›Full record

ArticleThe CRISPR journal2021

Expanding the Toolkit for Genome Editing in a Disease Vector,

Guan-Heng Zhu, Najla M Albishi, Xien Chen, Rachel L Brown, Subba Reddy Palli

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The CRISPR journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. CRISPR-Mediated Genome Engineering in Aedes aegypti.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Guan-Heng ZhuDepartment of Entomology, College of Agriculture, Food and Environment, University of Kentucky, Lexington, Kentucky, USA.
Najla M AlbishiDepartment of Entomology, College of Agriculture, Food and Environment, University of Kentucky, Lexington, Kentucky, USA.
Xien ChenDepartment of Entomology, College of Agriculture, Food and Environment, University of Kentucky, Lexington, Kentucky, USA.
Rachel L BrownDepartment of Entomology, College of Agriculture, Food and Environment, University of Kentucky, Lexington, Kentucky, USA.
Subba Reddy PalliDepartment of Entomology, College of Agriculture, Food and Environment, University of Kentucky, Lexington, Kentucky, USA.

Funding

Molecular Analysis of Juvenile Hormone ActionR01GM070559 · NIGMS · UNIVERSITY OF KENTUCKY · PI PALLI, SUBBA R · 2005 to 2024
$4.1M
RNAi methods for Zika virus vector controlR21AI131427 · NIAID · UNIVERSITY OF KENTUCKY · PI PALLI, SUBBA R · 2017 to 2018
$385k
NIAID NIH HHS R21 AI131427NIGMS NIH HHS R01 GM070559
6 · The paper itself

Abstract

CRISPR-Cas9 mediated genome editing methods are being used for the analysis of gene function. However, it is hard to identify gene knockout mutants for genes whose knockout does not cause distinct phenotypes. To overcome this issue in the disease vector,

Indexed as

AedesGene EditingAnimalsCRISPR-Cas SystemsDisease VectorsMosquito VectorsMutagenesisRNA, Guide, CRISPR-Cas SystemsRNA, Guide, CRISPR-Cas Systems

Identifiers

PMID33450159
PMCPMC8742270

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.