Evidence map›Paper›PMID 33449803›Full record

ArticleJCO global oncology2021

Predictors of Survival Outcomes After Primary Treatment of Epithelial Ovarian Cancer in Lagos, Nigeria.

Kehinde Sharafadeen Okunade, Adebola A Adejimi, Ephraim O Ohazurike, Omolola Salako, Benedetto Osunwusi, Muisi A Adenekan, Aloy O Ugwu, Adaiah Soibi-Harry, Olayemi Dawodu, Adeyemi A Okunowo and 2 more

Open access · goldAbstract read
In one paragraph

Article in JCO global oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Kehinde Sharafadeen OkunadeDepartment of Obstetrics & Gynaecology, College of Medicine, University of Lagos, Lagos, Nigeria.
Adebola A AdejimiDepartment of Obstetrics & Gynaecology, Lagos University Teaching Hospital, Lagos, Nigeria.
Ephraim O OhazurikeDepartment of Community Health and Primary Care, College of Medicine, University of Lagos, Surulere, Lagos, Nigeria.
Omolola SalakoDepartment of Clinical and Radiation Oncology, Lagos State University Teaching Hospital, Lagos, Nigeria.
Benedetto OsunwusiDepartment of Community Health and Primary Care, College of Medicine, University of Lagos, Surulere, Lagos, Nigeria.
Muisi A AdenekanDepartment of Community Health and Primary Care, College of Medicine, University of Lagos, Surulere, Lagos, Nigeria.
Aloy O UgwuDepartment of Community Health and Primary Care, College of Medicine, University of Lagos, Surulere, Lagos, Nigeria.
Adaiah Soibi-HarryDepartment of Community Health and Primary Care, College of Medicine, University of Lagos, Surulere, Lagos, Nigeria.
Olayemi DawoduDepartment of Anatomic and Molecular Pathology, College of Medicine, University of Lagos, Lagos, Nigeria.
Adeyemi A OkunowoDepartment of Obstetrics & Gynaecology, College of Medicine, University of Lagos, Lagos, Nigeria.
Rose I AnorluDepartment of Obstetrics & Gynaecology, College of Medicine, University of Lagos, Lagos, Nigeria.
Jonathan S BerekDepartment of Obstetrics & Gynaecology, Stanford University School of Medicine, Stanford, CA.
University of Lagos · NGLagos State University Teaching Hospital · NGLagos University Teaching Hospital · NGStanford University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study was designed to investigate the clinicopathologic predictors of progression-free survival (PFS) and overall survival (OS) in patients with epithelial ovarian cancer (EOC) following primary treatment in Lagos, Nigeria. MATERIALS AND

methodsUsing data from a retrospective cohort of 126 patients who received treatment for EOC between 2010 and 2018, we identified 83 patients with a complete clinical record for subsequent data analysis. Patients' demographics and updated 2-year follow-up status were abstracted from medical records. Kaplan-Meier survival curves were compared using the log-rank test, and Cox proportional hazard models were used for multivariate analysis to identify independent predictors of survivals following treatment in EOC patients.

resultsThe median PFS and OS were 12 and 24 months, respectively. After adjusting for covariates in the multivariate analysis, younger age ≤ 55 years (hazard ratio [HR] = 0.40; 95% CI, 0.22 to 0.74;

conclusionPFS could be predicted by the age and FIGO stage of the disease, whereas menopausal status was predictive of OS in patients with EOC. This knowledge should form the basis for counseling patients with ovarian cancer during their primary treatment and lend support to the importance of aggressive follow-up and monitoring for the older, premenopausal patients and those with an advanced stage of epithelial ovarian cancer. However, robust longitudinal research should be carried out to provide additional reliable insight to this information.

Indexed as

Ovarian NeoplasmsCarcinoma, Ovarian EpithelialFemaleHumansKaplan-Meier EstimateMiddle AgedNigeriaRetrospective Studies

Identifiers

PMID33449803
PMCPMC8081541
OpenAlexW3119629670

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.