ArticleNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics2021
Effect of Capsaicinoids on Neurophysiological, Biochemical, and Mechanical Parameters of Swallowing Function.
Article in Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 4 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- A Meta-Analysis and Systematic Review of the Effects of Sensory Modulation Treatments for Neurogenic Oropharyngeal Dysphagia.CNS neuroscience & therapeutics · 2025Pooled it
- The global prevalence of oropharyngeal dysphagia in different populations: a systematic review and meta-analysis.Journal of translational medicine · 2022Pooled it
- Effects of pharmacological agents for neurogenic oropharyngeal dysphagia: A systematic review and meta-analysis.Neurogastroenterology and motility · 2022Pooled it
- The therapeutic effect of capsaicin on oropharyngeal dysphagia: A systematic review and meta-analysis.Frontiers in aging neuroscience · 2022Pooled it
- Effects of Combined Transcranial Direct Current Stimulation and Oral Capsaicinoids on Swallowing Function: A Randomized Controlled Trial.Journal of oral rehabilitation · 2026Trial
- An oral nutritional supplement with TRPM8 agonists as a cooling flavor improved swallowing function in post-stroke patients with oropharyngeal dysphagia.Scientific reports · 2026Trial
- Metaplasticity in swallowing system via cross-modal neurostimulation: A randomized crossover trial with magnetoencephalography.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Trial
- Facilitation of oral sensitivity by electrical stimulation of the faucial pillars.Scientific reports · 2021Trial
- Association Between Salivary Substance P and Aspiration on Videofluoroscopic Swallow Study in Infants and Toddlers.The Journal of pediatrics · 2026Article
- Article
- Dysphagia and gastrointestinal disorders in Parkinson's disease: towards a diagnostic standard operating procedure for the interprofessional neurological outpatient care team.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- Mechanisms of Improving Feeding Function With Capsaicin Following Local Anesthesia in Infant Pigs.The Laryngoscope · 2025Article
- Review
- Brainstem Stroke and Dysphagia Treatment: A Narrative Review on the Role of Neuromodulation, Skill-Based Swallowing Training and Transient Receptor Potential Agonists.Audiology research · 2025Review
- Post-extubation dysphagia in the ICU-a narrative review: epidemiology, mechanisms and clinical management (Update 2025).Critical care (London, England) · 2025Review
- Capsaicin Modulates Ruminal Fermentation and Bacterial Communities in Beef Cattle with High-Grain Diet-Induced Subacute Ruminal Acidosis.Microorganisms · 2025Article
- Normative High-Resolution Pharyngeal Manometry: Impact of Age, Size of System, and Sex on Primary Metrics and Pressure Stability.Dysphagia · 2024Article
- The effects of simulated gastroesophageal reflux on infant pig oropharyngeal feeding physiology.American journal of physiology. Gastrointestinal and liver physiology · 2024Article
- Identifying Non-Traditional Approaches to Swallowing Rehabilitation: A Scoping Review.Dysphagia · 2024Article
- Transient receptor potential channels as an emerging therapeutic target for oropharyngeal dysphagia.The Japanese dental science review · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oropharyngeal dysphagia is prevalent in age-related neurological disorders presenting with impaired efficacy and safety of swallowing due to a loss of muscle force and sensory deficits. Stimulating the oropharynx with capsaicin that mediates Substance P release is an emerging pharmacological treatment option which needs further scientific evidence. Our aim was to comprehensively evaluate the effect of capsaicin on biochemical, neurophysiological, and biomechanical parameters of swallowing function. In a randomized study on healthy individuals, the impact of orally administered capsaicinoids at different dosages and application durations in comparison to non-carbonated water was evaluated. Time course and magnitude of salivary Substance P increase were monitored. Magnetoencephalography was used to detect cortical swallowing network alterations. Modifications in swallowing biomechanics were measured applying high-resolution pharyngeal manometry. Capsaicinoids at 10 μmol/L improved swallowing efficacy as seen by a significant increase of pharyngeal contractile integral and upper esophageal sphincter activation and relaxation times in manometry. Significant improvement of precision in a challenging swallow task accompanied by a reduction in swallowing-related submental electromyographic power was observed with capsaicinoids preconditioning at 10 μmol/L over 5 min, but not with continuous stimulation. The cortical activation pattern remained unchanged after any intervention. A significant increase of salivary Substance P was not detected with 10 μmol/L but with 50 μmol/L and lasted for 15 min after application. Capsaicinoids mediate dose-dependent Substance P release and positively alter swallowing biomechanics in healthy subjects. The results provide supportive evidence for the value of natural capsaicinoids to improve swallowing function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.