Evidence map›Paper›PMID 33449236›Full record

ArticleAIDS and behavior2021

HIV Infection and Depression Among Opiate Users in a US Epicenter of the Opioid Epidemic.

Cecile M Denis, Tiffany Dominique, Peter Smith, Danielle Fiore, Yi-Chien Ku, Angus Culhane, Debora Dunbar, Dana Brown, Menvekeh Daramay, Chelsea Voytek and 10 more

Open access · bronzeAbstract read
In one paragraph

Article in AIDS and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 3 institutions in 1 country.

Cecile M DenisDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. cdenis@pennmedicine.upenn.edu.ORCID http://orcid.org/0000-0002-0903-6080
Tiffany DominiqueDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Peter SmithDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Danielle FioreDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Yi-Chien KuDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Angus CulhaneDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Debora DunbarDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Dana BrownDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Menvekeh DaramayDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Chelsea VoytekDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Knashawn H MoralesDepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Michael B BlankDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Paul F Crits-ChristophDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Steven D DouglasThe Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Serguei SpitsinThe Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Ian FrankDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Krystal Colon-RiveraThe Wistar Institute, Philadelphia, PA, USA.
Luis J MontanerThe Wistar Institute, Philadelphia, PA, USA.
David S MetzgerDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Dwight L EvansDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
University of Pennsylvania · USChildren's Hospital of Philadelphia · USThe Wistar Institute · US

Funding

Virus & Reservoirs CoreP30AI045008 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Ronald G Collman · 1999 to 2026
$78.6M
University of Pennsylvania HIV Clinical Trials UnitUM1AI069534 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Ian Frank, PABLO TEBAS · 2012 to 2026
$33.0M
First-in-human study of two anti-SARS CoV-2 antibodies in health volunteersUM1AI126620 · NIAID · WISTAR INSTITUTE · PI MONTANER, LUIS J, RILEY, JAMES L. · 2016 to 2021
$24.5M
Penn Mental Health AIDS Research CenterP30MH097488 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI Karine Dube, Kelly L Jordan-Sciutto · 2013 to 2026
$23.5M
Effects of mu-opiate receptor engagement on microbial translocation and residual immune activation in HIV-infected, ART suppressed opioid use disorder patents initiating medication-assisted treatmentR01DA048728 · NIDA · WISTAR INSTITUTE · PI METZGER, DAVID S, MONTANER, LUIS J · 2019 to 2023
$8.4M
Effects of Mu-opiate receptor engagement on the persistence of HIV-associated activation and viral reservoirs in individuals receiving medication assisted treatment for opioid use disorderR01DA049666 · NIDA · WISTAR INSTITUTE · PI MONTANER, LUIS J · 2019 to 2023
$4.2M
National Institute of Allergy and Infectious Diseases 1UM1Al126620National Institute of Allergy and Infectious Diseases P30-AI-045008NIAID NIH HHS P30 AI045008NIAID NIH HHS UM1 AI069534NIDA NIH HHS R01 DA048728NIDA NIH HHS R01DA048728NIDA NIH HHS R01 DA049666NIDA NIH HHS R01DA049666NIMH NIH HHS P30 MH097488NIMH NIH HHS P30-MH-097488
6 · The paper itself

Abstract

Using a mobile research facility, we enrolled 141 opioid users from a neighborhood of Philadelphia, an urban epicenter of the opioid epidemic. Nearly all (95.6%) met DSM-5 criteria for severe opioid use disorder. The prevalence of HIV infection (8.5%) was more than seven times that found in the general population of the city. Eight of the HIV-positive participants (67.0%) reported receiving antiretroviral treatment but almost all of them had unsuppressed virus (87.5%). The majority of participants (57.4%) reported symptoms consistent with major depressive disorder. Severe economic distress (60.3%) and homelessness were common (57%). Polysubstance use was nearly universal, 72.1% had experienced multiple overdoses and prior medication for opioid use disorder (MOUD) treatment episodes (79.9%), but few currently engaged in addiction care. The prevalence, multiplicity and severity of chronic health and socioeconomic problems highlight consequences of the current opioid epidemic and underscore the urgent need to develop integrated models of treatment.

Indexed as

BuprenorphineHIV InfectionsMajor Depressive DisorderOpiate AlkaloidsOpioid-Related DisordersAnalgesics, OpioidDepressionHumansOpioid EpidemicPhiladelphiaAnalgesics, OpioidBuprenorphineOpiate AlkaloidsDepressionHIVMOUDOpioidRisk behavior

Identifiers

PMID33449236
PMCPMC7809894
OpenAlexW3118357848

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.