Evidence map›Paper›PMID 33449212›Full record

ArticlePflugers Archiv : European journal of physiology2021

A novel mutation in KCNH2 yields loss-of-function of hERG potassium channel in long QT syndrome 2.

Kai Gu, Duoduo Qian, Huiyuan Qin, Chang Cui, W C Hewith A Fernando, Daowu Wang, Juejin Wang, Kejiang Cao, Minglong Chen

Abstract read
PubMed Publisher
In one paragraph

Article in Pflugers Archiv : European journal of physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Aborted Cardiac Arrest in LQT2 Related to NovelMedicina (Kaunas, Lithuania) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Kai Gu *Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, China.
Duoduo Qian *Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, China.
Huiyuan QinDepartment of Cardiology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, China.
Chang CuiDepartment of Cardiology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, China.
W C Hewith A FernandoDepartment of Physiology, Nanjing Medical University, 101 Longmian Ave, Nanjing, 211166, China.
Daowu WangDepartment of Cardiology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, China.
Juejin WangDepartment of Physiology, Nanjing Medical University, 101 Longmian Ave, Nanjing, 211166, China. juejinwang@njmu.edu.cn.ORCID 0000-0003-4921-5451
Kejiang CaoDepartment of Cardiology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, China. kjcao@njmu.edu.cn.
Minglong ChenDepartment of Cardiology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, China. chenminglong@njmu.edu.cn.
Jiangsu Province Hospital · CNNanjing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mutations in hERG (human ether-à-go-go-related gene) potassium channel are closely associated with long QT syndromes. By direct Sanger sequencing, we identified a novel KCNH2 mutation W410R in the patient with long QT syndrome 2 (LQT2). However, the electrophysiological functions of this mutation remain unknown. In comparison to hERG

Indexed as

Loss of Function MutationAction PotentialsERG1 Potassium ChannelGenetic Predisposition to DiseaseHeart RateHEK293 CellsHumansLong QT SyndromeModels, CardiovascularPhenotypeTime FactorsERG1 Potassium ChannelKCNH2 protein, humanElectrophysiologyhERG channelLong QT syndrome 2Mutation

Identifiers

PMID33449212
OpenAlexW3121130479

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.