Evidence map›Paper›PMID 33449153›Full record

ReviewCellular and molecular life sciences : CMLS2021

Mechanisms of fungal dissemination.

Ashley B Strickland, Meiqing Shi

Open access · greenAbstract readReview
In one paragraph

Review in Cellular and molecular life sciences : CMLS, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed
11.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

81 citing papers in PubMed, 116 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Acetylation and accessibility ofCell surface (Amsterdam, Netherlands) · 2026
    Article
  6. Article
  7. Article
  8. Polymers · 2026
    Article
  9. Article
  10. Fungal meningoencephalitis caused byMedical mycology case reports · 2026
    Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article

21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Ashley B StricklandDivision of Immunology, Virginia-Maryland College of Veterinary Medicine and Maryland Pathogen Research Institute, University of Maryland, College Park, MD, USA. astrick1@umd.edu.
Meiqing ShiDivision of Immunology, Virginia-Maryland College of Veterinary Medicine and Maryland Pathogen Research Institute, University of Maryland, College Park, MD, USA. mshi@umd.edu.ORCID http://orcid.org/0000-0001-9890-8807
Virginia–Maryland College of Veterinary Medicine · US

Funding

In vivo mechanisms of brain invasion by Cryptococcus neoformansR01AI131905 · NIAID · UNIV OF MARYLAND, COLLEGE PARK · PI SHI, MEIQING · 2017 to 2021
$1.9M
Filtering of disseminating Cryptococcus neoformans out of vasculatureR21AI131219 · NIAID · UNIV OF MARYLAND, COLLEGE PARK · PI SHI, MEIQING · 2017 to 2018
$418k
NIAID NIH HHS R01 AI131905NIAID NIH HHS R21 AI131219NIH HHS AI131219NIH HHS AI131905
6 · The paper itself

Abstract

Fungal infections are an increasing threat to global public health. There are more than six million fungal species worldwide, but less than 1% are known to infect humans. Most of these fungal infections are superficial, affecting the hair, skin and nails, but some species are capable of causing life-threatening diseases. The most common of these include Cryptococcus neoformans, Aspergillus fumigatus and Candida albicans. These fungi are typically innocuous and even constitute a part of the human microbiome, but if these pathogens disseminate throughout the body, they can cause fatal infections which account for more than one million deaths worldwide each year. Thus, systemic dissemination of fungi is a critical step in the development of these deadly infections. In this review, we discuss our current understanding of how fungi disseminate from the initial infection sites to the bloodstream, how immune cells eliminate fungi from circulation and how fungi leave the blood and enter distant organs, highlighting some recent advances and offering some perspectives on future directions.

Indexed as

AnimalsAntifungal AgentsFungiHost-Pathogen InteractionsHumansMycosesVirulenceAntifungal AgentsAspergillus fumigatusCandida albicansCryptococcus neoformansFungal pathogenesisFungusInvasive aspergillosisInvasive candidiasisMeningoencephalitisParacellular crossingTranscytosisTrojan horse

Identifiers

PMID33449153
PMCPMC8044058
OpenAlexW3120229614

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.