ArticleInternational journal of colorectal disease2021
Defining early recurrence in patients with resected primary colorectal carcinoma and its respective risk factors.
Article in International journal of colorectal disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed.
- Emergency surgery for malignant large bowel obstruction: Assessing management options and outcomes.World journal of gastrointestinal surgery · 2026Article
- Primary tissue metabolic fingerprinting for efficient diagnosis of lymph node metastasis and metabolic reprogramming mechanisms in colorectal cancer.Materials today. Bio · 2026Article
- Pretreatment comprehensive nutritional index predicts survival in locally advanced rectal cancer after neoadjuvant chemoradiotherapy and surgery.Biomolecules & biomedicine · 2026Article
- Influencing factors and predictive model of the early postoperative recurrence of colorectal cancer with obstruction.World journal of gastrointestinal surgery · 2025Article
- Article
- Definition and Predictors of Early Recurrence in Neoadjuvantly Treated Esophageal and Gastroesophageal Adenocarcinoma: a Dual-Center Retrospective Cohort Study.Annals of surgical oncology · 2025Article
- Post recurrence survival in early versus late period and its prognostic factors in rectal cancer patients.Scientific reports · 2024Article
- Influence of the initial recurrence site on prognosis after radical surgery for colorectal cancer: a retrospective cohort study.World journal of surgical oncology · 2023Article
- NCR, an Inflammation and Nutrition Related Blood-Based Marker in Colon Cancer Patients: A New Promising Biomarker to Predict Outcome.Diagnostics (Basel, Switzerland) · 2022Article
- Article
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8 authors.
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Abstract
purposeThere is no evidence-based definition of early recurrence following resection of colorectal cancer. The purpose of this study is to define a point that discriminates between early and late recurrence in patients who have undergone colorectal cancer resection with curative intent and to analyze associated risk factors.
methodsA retrospective single-center cohort study was performed at a university hospital recognized as a comprehensive cancer center, specializing in colorectal cancer surgery. Patient data were retrieved from a prospectively maintained institutional database. Included patients underwent resection for primary, non-metastatic colorectal carcinomas with curative intent between 1995 and 2010. Aims of the study were (1) to define the optimal cut-off point of recurrence-free survival based on overall survival using a minimum p value approach and (2) to identify patterns of initial recurrence and putative risk factors for early recurrence using regression models.
resultsRecurrence was diagnosed in 412 of 1893 patients. Statistical analysis suggested that a recurrence-free survival of 16 months could be used to distinguish between early and late recurrence based on overall survival (p < 0.001). Independent risk factors for early recurrence included advanced pT categories (pT3,4/ypT3,4) and positive lymph node status (pN+/ypN+). Early recurrence was independent of site of recurrence and was associated with worse prognosis.
conclusionsRecurrence of colorectal carcinoma within 16 months after primary treatment should be labeled as "early." Tumor categories pT3,4/ypT3,4 and positive lymph node status pN+/ypN+ are predictive of early recurrence.
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