ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2021
Multimorbidity Patterns and Memory Trajectories in Older Adults: Evidence From the English Longitudinal Study of Aging.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Multimorbidity patterns and mental health in late life: a systematic review of longitudinal studies.European geriatric medicine · 2026Pooled it
- Pooled it
- Social determinants of multimorbidity patterns: A systematic review.Frontiers in public health · 2023Pooled it
- Association Between Activities of Daily Living Profiles and Memory Decline in Community-Dwelling Older Adults Without Cognitive Impairment: An Observational Panel Study.Journal of advanced nursing · 2026Observational
- Effects of household and neighbourhood attributes on four definitions of multimorbidity: a comparative multilevel analysis of linked clinical and census data of Wales.BMJ public health · 2026Article
- Cardiometabolic Multimorbidity and Dementia Onset Among Middle-Aged and Older Adults: Differences by Race/Ethnicity.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Observational
- Uncovering bridging diseases in complex multimorbidity pathways: A network science approach.PloS one · 2025Article
- The extent and burden of high multimorbidity on older adults in the US: a descriptive analysis of Medicare beneficiaries.BMC geriatrics · 2024Article
- Multimorbidity measures associated with cognitive function among community-dwelling older Chinese adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Learning prevalent patterns of co-morbidities in multichronic patients using population-based healthcare data.Scientific reports · 2024Article
- Multimorbidity, healthy lifestyle, and the risk of cognitive impairment in Chinese older adults: a longitudinal cohort study.BMC public health · 2024Article
- The effect of multimorbidity patterns on physical and cognitive function in diabetes patients: a longitudinal cohort of middle-aged and older adults in China.Frontiers in aging neuroscience · 2024Article
- Genetic effects and causal association analyses of 14 common conditions/diseases in multimorbidity patterns.PloS one · 2024Article
- Epidemiology, mortality, and health service use of local-level multimorbidity patterns in South Spain.Nature communications · 2023Article
- The Role of Methionine-Rich Diet in Unhealthy Cerebrovascular and Brain Aging: Mechanisms and Implications for Cognitive Impairment.Nutrients · 2023Review
- Effects of multimorbidity patterns and socioeconomic status on catastrophic health expenditure of widowed older adults in China.Frontiers in public health · 2023Article
- Multimorbid Patterns and Cognitive Performance in the Presence of Informative Dropout Among Community-Dwelling Taiwanese Older Adults.Innovation in aging · 2023Article
- Social inequalities in multimorbidity patterns in Europe: A multilevel latent class analysis using the European Social Survey (ESS).SSM - population health · 2022Article
- Association between age at onset of multimorbidity and incidence of dementia: 30 year follow-up in Whitehall II prospective cohort study.BMJ (Clinical research ed.) · 2022Article
- Trajectory of multimorbidity before dementia: A 24-year follow-up study.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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4 authors.
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Abstract
backgroundWe aimed to examine the multimorbidity patterns within a representative sample of UK older adults and their association with concurrent and subsequent memory.
methodsOur sample consisted of 11 449 respondents (mean age at baseline was 65.02) from the English Longitudinal Study of Aging (ELSA). We used 14 health conditions and immediate and delayed recall scores (IMRC and DLRC) over 7 waves (14 years of follow-up). Latent class analyses were performed to identify the multimorbidity patterns and linear mixed models were estimated to explore their association with their memory trajectories. Models were adjusted by sociodemographics, body mass index (BMI), and health behaviors.
resultsResults showed 8 classes: Class 1: Heart Disease/Stroke (26%), Class 2: Asthma/Lung Disease (16%), Class 3: Arthritis/Hypertension (13%), Class 4: Depression/Arthritis (12%), Class 5: Hypertension/Cataracts/Diabetes (10%), Class 6: Psychiatric Problems/Depression (10%), Class 7: Cancer (7%), and Class 8: Arthritis/Cataracts (6%). At baseline, Class 4 was found to have lower IMRC and DLRC scores and Class 5 in DLRC, compared to the no multimorbidity group (n = 6380, 55.72% of total cohort). For both tasks, in unadjusted models, we found an accelerated decline in Classes 1, 3, and 8; and, for DLRC, also in Classes 2 and 5. However, it was fully attenuated after adjustments.
conclusionsThese findings suggest that individuals with certain combinations of health conditions are more likely to have lower levels of memory compared to those with no multimorbidity and their memory scores tend to differ between combinations. Sociodemographics and health behaviors have a key role to understand who is more likely to be at risk of an accelerated decline.
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