Evidence map›Paper›PMID 33448867›Full record

ArticleClinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis

Endothelial Function in Patients With Von Willebrand Disease.

Stephanie Noone, Ralf Schubert, Stephan Fichtlscherer, Thomas Hilberg, Sonja Alesci, Wolfgang Miesbach

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Stephanie NooneHaemostaseology, Department of Internal Medicine II, Institute of Transfusion Medicine, University Hospital, Goethe University Frankfurt am Main, Frankfurt, Germany.ORCID https://orcid.org/0000-0002-6755-0539
Ralf SchubertDepartment for Children and Adolescents Medicine, University Hospital Frankfurt, Frankfurt am Main, Germany.
Stephan FichtlschererDivision of Cardiology, Department of Internal Medicine III, University Hospital Frankfurt, Frankfurt am Main, Germany.
Thomas HilbergDepartment of Sports Medicine, University of Wuppertal, Wuppertal, Germany.
Sonja AlesciIMD Blood Coagulation Centre, Bad Homburg, Germany.
Wolfgang MiesbachHaemostaseology, Department of Internal Medicine II, Institute of Transfusion Medicine, University Hospital, Goethe University Frankfurt am Main, Frankfurt, Germany.ORCID https://orcid.org/0000-0002-4506-0061
Goethe University Frankfurt · DEUniversity of Wuppertal · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In patients with von Willebrand disease (vWD) the interest in age-related comorbidities has grown, because the life expectancy of these patients has increased. The research question of this study was whether patients with vWD show a different endothelial function compared to the general population. A total of 37 patients with type 1 (n = 23), type 2 (n = 10) and type 3 (n = 4) vWD, 14 controls and 38 patients with coronary artery disease (CAD) were included in this study. Five markers of endothelial dysfunction (MOED) were determined. Moreover, the endothelial function was examined using the Itamar Endo-PAT. The reactive hyperemia index (RHI) was calculated from the results. The markers soluble intercellular adhesion molecule-1 (p = 0.171), P-Selectin (p = 0.512), interleukin-6 (p = 0.734) and monocyte chemoattractant protein-1 (p = 0.761) showed higher levels in patients with vWD, but were not significantly different compared to the control group. RHI was impaired in CAD-patients (1.855), whereas vWD patients had mean results of 1.870 and controls 2.112 (p = 0.367). In this study, the endothelial function measurements of patients with von Willebrand disease were not significantly different compared to healthy controls.

Indexed as

AdultBiomarkersCase-Control StudiesChemokine CCL2Coronary Artery DiseaseEndothelium, VascularFemaleHumansHyperemiaIntercellular Adhesion Molecule-1Interleukin-6MaleMiddle AgedP-Selectinvon Willebrand Diseasesvon Willebrand Disease, Type 1BiomarkersCCL2 protein, humanChemokine CCL2ICAM1 protein, humanIL6 protein, humanIntercellular Adhesion Molecule-1Interleukin-6P-SelectinSELP protein, humancomorbiditycoronary artery diseaseendothelial functionvon Willebrand disease

Identifiers

PMID33448867
PMCPMC7812404
OpenAlexW3122794500

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.