ArticleAngewandte Chemie (International ed. in English)2021
Total Synthesis of Mycinolide IV and Path-Scouting for Aldgamycin N.
Article in Angewandte Chemie (International ed. in English), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Advances in Ligand Development for Wacker-Type Oxidation.ACS omega · 2026Review
- Total Synthesis ofJournal of the American Chemical Society · 2026Article
- Iron-Catalyzed trans-Hydrostannation of Terminal Alkynes.Angewandte Chemie (International ed. in English) · 2025Article
- A Very Readily Prepared Ligand for Rhodium Catalyzed Propene Hydroformylation.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Ligand Hydrogenation during Hydroformylation Catalysis Detected by In Situ High-Pressure Infra-Red Spectroscopic Analysis of a Rhodium/Phospholene-Phosphite Catalyst.Molecules (Basel, Switzerland) · 2024Article
- Mukaiyama aldol reaction: an effective asymmetric approach to access chiral natural products and their derivatives/analogues.RSC advances · 2023Review
- Ruthenium-Catalyzed Butadiene-Mediated Crotylation and Oxazaborolidine-Catalyzed Vinylogous Mukaiyama Aldol Reaction for The Synthesis of C1-C19 and C23-C35 of Neaumycin B.Angewandte Chemie (International ed. in English) · 2022Article
- Samarium(ii) iodide-mediated reactions applied to natural product total synthesis.RSC advances · 2022Review
- Total Synthesis of Mycinamicin IV as Integral Part of a Collective Approach to Macrolide Antibiotics.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Article
- Regioselective trans-Hydrostannation of Boron-Capped Alkynes.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- Total Synthesis of Mycinolide IV and Path-Scouting for Aldgamycin N.Angewandte Chemie (International ed. in English) · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Proof-of-concept is provided that a large estate of 16-membered macrolide antibiotics can be reached by a "unified" approach. The key building block was formed on scale by an asymmetric vinylogous Mukaiyama aldol reaction; its alkene terminus was then converted either into the corresponding methyl ketone by Wacker oxidation or into a chain-extended aldehyde by catalyst-controlled branch-selective asymmetric hydroformylation. These transformations ultimately opened access to two structurally distinct series of macrolide targets. Notable late-stage maneuvers comprise a rare example of a ruthenium-catalyzed redox isomerization of an 1,3-enyne-5-ol into a 1,3-diene-5-one derivative, as well as the elaboration of a tertiary propargylic alcohol into an acyloin by trans-hydrostannation/Chan-Lam-type coupling. Moreover, this case study illustrates the underutilized possibility of forging complex macrolactone rings by transesterification under essentially neutral conditions.
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