Evidence map›Paper›PMID 33448466›Full record

Trial reportJournal of inherited metabolic disease2021

Effects of acute nutritional ketosis during exercise in adults with glycogen storage disease type IIIa are phenotype-specific: An investigator-initiated, randomized, crossover study.

Irene J Hoogeveen, Foekje de Boer, Willemijn F Boonstra, Caroline J van der Schaaf, Ulrike Steuerwald, Anita J Sibeijn-Kuiper, Riemer J K Vegter, Johannes H van der Hoeven, M Rebecca Heiner-Fokkema, Kieran C Clarke and 3 more

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of inherited metabolic disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Review
  7. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 3 countries.

Irene J HoogeveenSection of Metabolic Diseases, Beatrix Children's Hospital, University of Groningen, University Medical Center of Groningen, Groningen, The Netherlands.
Foekje de BoerSection of Metabolic Diseases, Beatrix Children's Hospital, University of Groningen, University Medical Center of Groningen, Groningen, The Netherlands.
Willemijn F BoonstraSection of Metabolic Diseases, Beatrix Children's Hospital, University of Groningen, University Medical Center of Groningen, Groningen, The Netherlands.
Caroline J van der SchaafSection of Metabolic Diseases, Beatrix Children's Hospital, University of Groningen, University Medical Center of Groningen, Groningen, The Netherlands.
Ulrike SteuerwaldNational Hospital of the Faroe Islands, Medical Center, Tórshavn, Faroe Islands.
Anita J Sibeijn-KuiperNeuroimaging Center, Department of Neuroscience, University Medical Center Groningen, Groningen, The Netherlands.
Riemer J K VegterCenter for Human Movement Sciences, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Johannes H van der HoevenDepartment of Neurology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.
M Rebecca Heiner-FokkemaDepartment of Laboratory Medicine, Laboratory of Metabolic Diseases, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Kieran C ClarkeDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.
Pete J CoxDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.
Terry G J DerksSection of Metabolic Diseases, Beatrix Children's Hospital, University of Groningen, University Medical Center of Groningen, Groningen, The Netherlands.ORCID 0000-0002-7259-1095
Jeroen A L JenesonNeuroimaging Center, Department of Neuroscience, University Medical Center Groningen, Groningen, The Netherlands.
University Medical Center Groningen · NLUniversity of Oxford · GBUniversity of the Faroe Islands · FO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glycogen storage disease type IIIa (GSDIIIa) is an inborn error of carbohydrate metabolism caused by a debranching enzyme deficiency. A subgroup of GSDIIIa patients develops severe myopathy. The purpose of this study was to investigate whether acute nutritional ketosis (ANK) in response to ketone-ester (KE) ingestion is effective to deliver oxidative substrate to exercising muscle in GSDIIIa patients. This was an investigator-initiated, researcher-blinded, randomized, crossover study in six adult GSDIIIa patients. Prior to exercise subjects ingested a carbohydrate drink (~66 g, CHO) or a ketone-ester (395 mg/kg, KE) + carbohydrate drink (30 g, KE + CHO). Subjects performed 15-minute cycling exercise on an upright ergometer followed by 10-minute supine cycling in a magnetic resonance (MR) scanner at two submaximal workloads (30% and 60% of individual maximum, respectively). Blood metabolites, indirect calorimetry data, and in vivo

Indexed as

BeveragesExerciseAdultBlood GlucoseCarbohydrate MetabolismCross-Over StudiesDietary CarbohydratesDiet, KetogenicEstersFemaleGlycogen Storage Disease Type IIIHumansKetonesKetosisMaleMiddle AgedBlood GlucoseDietary CarbohydratesEstersKetones31P-MRSacute nutritional ketosisexerciseglycogen storage diseaseketone-ester

Identifiers

PMID33448466
PMCPMC7891643
OpenAlexW3049507103

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.