Evidence map›Paper›PMID 33448439›Full record

SynthesisJournal of medical virology2021

Association between red blood cell distribution width and mortality and severity among patients with COVID-19: A systematic review and meta-analysis.

Jane J Lee, Sahar M Montazerin, Adeel Jamil, Umer Jamil, Jolanta Marszalek, Michael L Chuang, Gerald Chi

Abstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Journal of medical virology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  4. Observational
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  8. Observational
  9. Red Blood Cell Distribution Width Is Not a Predictor of Hospital Mortality in Elderly and Nonelderly COVID-19-Infected Patients: A Prospective Study at a Brazilian Quaternary University Hospital.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2025
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  17. Hypothermal opto-thermophoretic tweezers.Nature communications · 2023
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Jane J LeeTrial Design and Development, Baim Institute for Clinical Research, Boston, Massachusetts, USA.ORCID 0000-0002-6276-7667
Sahar M MontazerinDivision of Cardiovascular Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Adeel JamilDepartment of Medicine, OSF Saint Francis Medical Center, Peoria, Illinois, USA.
Umer JamilDepartment of Medicine, OSF Saint Francis Medical Center, Peoria, Illinois, USA.
Jolanta MarszalekDepartment of Neurology, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, California, USA.
Michael L ChuangDivision of Cardiovascular Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Gerald ChiDivision of Cardiovascular Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Emerging evidence has underscored the potential usefulness of red blood cell distribution width (RDW) measurement in predicting the mortality and disease severity of COVID-19. This study aimed to assess the association of the plasma RDW levels with adverse prognosis in COVID-19 patients. A comprehensive literature search from inception to September 2020 was performed to harvest original studies reporting RDW on admission and clinical outcomes among patients hospitalized with COVID-19. RDW levels were compared between cases (patients who died or developed more severe symptoms) and controls (patients who survived or developed less severe symptoms). A total of 14,866 subjects from 10 studies were included in the meta-analysis. Higher levels of RDW were associated with adverse outcomes in COVID-19 patients (mean differences = 0.72; 95% CI = 0.47-0.97; I

Indexed as

BiomarkersCOVID-19Databases, FactualErythrocyte IndicesErythrocytesHospital MortalityHumansPrognosisSARS-CoV-2Severity of Illness IndexBiomarkersbiomarkersCOVID-19erythrocyte indicesred blood cell distribution widthsevere acute respiratory syndrome coronavirus 2

Identifiers

PMID33448439
PMCPMC8014709

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.