Evidence map›Paper›PMID 33448368›Full record

ArticleEuropean journal of immunology2021

IL-18: A potential inflammation biomarker in Wiskott-Aldrich syndrome.

Elizabeth Rivers, Ying Hong, Mona Bajaj-Elliott, Austen Worth, Adrian J Thrasher

Open access · hybridAbstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Elizabeth RiversUCL Great Ormond Street Institute of Child Health, London, UK.ORCID 0000-0001-5814-8014
Ying HongUCL Great Ormond Street Institute of Child Health, London, UK.
Mona Bajaj-ElliottUCL Great Ormond Street Institute of Child Health, London, UK.
Austen WorthGreat Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
Adrian J ThrasherUCL Great Ormond Street Institute of Child Health, London, UK.ORCID 0000-0002-6097-6115
Great Ormond Street Hospital · GBGreat Ormond Street Hospital for Children NHS Foundation Trust · GB

Funding

Department of HealthWellcome TrustWellcome Trust 090233/Z/09/ZWellcome Trust 201250/Z/16/Z
6 · The paper itself

Abstract

Analysis of serum cytokine levels in Wiskott-Aldrich syndrome patients pre- and post- treatment reveals IL-18 as a stable and reliable marker of inflammation. Definitive stem cell treatment with good myeloid correction correlates with resolution of inflammation and reduction of circulating IL-18, highlighting the importance of actin cytoskeletal regulation of myeloid cells in control of inflammation.

Indexed as

BiomarkersCytokinesDisease SusceptibilityHumansInflammation MediatorsInterleukin-18Wiskott-Aldrich SyndromeBiomarkersCytokinesInflammation MediatorsInterleukin-18

Identifiers

PMID33448368
PMCPMC8436742
OpenAlexW3120762647

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.