Evidence map›Paper›PMID 33448173›Full record

ArticleZhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences2020

[Protective effect of iridoid glycosides of radix scrophulariae on endoplasmic reticulum stress induced by oxygen-glucose deprivation and reperfusion

Jiayi Ye, Hengpei Gong, Lingfeng Wang, Zhen Huang, Fengmei Qiu, Xiaoming Zhong

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.1field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. Pooled it
  2. Piceatannol protects rat neuron cells from oxygen-glucose deprivation reperfusion injury via regulation of GSK-3β/Nrf2 signaling pathway.Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jiayi YeCollege of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou 311402, China.
Hengpei GongCollege of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou 311402, China.
Lingfeng WangCollege of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou 311402, China.
Zhen HuangCollege of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou 311402, China.
Fengmei QiuCollege of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou 311402, China.
Xiaoming ZhongCollege of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou 311402, China.
Zhejiang Chinese Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the regulatory effect of iridoid glycoside of radix scrophulariae (IGRS) on endoplasmic reticulum stress induced by oxygen-glucose deprivation and reperfusion

methodsRat pheochromocytoma PC12 cells were pretreated with IGRS (50, 100, 200 μg/mL) for 24h, and the

resultsThe damage caused by OGD/R to PC12 cells was significantly reduced by IGRS, with significant effect on increasing survival rate and reducing LDH release (all

conclusionsIGRS has neuroprotective effect, which may alleviate cerebral ischemia-reperfusion injury by regulating SERCA2, maintaining calcium balance, and inhibiting endoplasmic reticulum stress-mediated apoptosis.

Indexed as

Endoplasmic Reticulum StressIridoid GlycosidesReperfusion InjurySnailsAnimalsCell SurvivalDown-RegulationGlucoseIn Vitro TechniquesOxygenPC12 CellsRatsReperfusionGlucoseIridoid GlycosidesOxygenApoptosisCalcium homeostasisCellsEndoplasmic reticulum stressIridoid glycosides of radix scrophulariaeOxygen-glucose deprivation-reperfusion

Identifiers

PMID33448173
PMCPMC10412414
OpenAlexW3122081531

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.