Evidence map›Paper›PMID 33448101›Full record

ArticlePhytotherapy research : PTR2021

In silico and in vitro evaluation of kaempferol as a potential inhibitor of the SARS-CoV-2 main protease (3CLpro).

Abbas Khan, Wang Heng, Yanjing Wang, Jingfei Qiu, Xiaoyong Wei, Shaoliang Peng, Shoaib Saleem, Mazhar Khan, Syed Shujait Ali, Dong-Qing Wei

Abstract readLetterComment
In one paragraph

Article in Phytotherapy research : PTR, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Bioassay-Guided Phytochemical Investigation of VietnameseMolecules (Basel, Switzerland) · 2026
    Article
  6. Article
  7. Insights into Molecular Mechanisms of Polyphenolic Compounds fromPharmaceuticals (Basel, Switzerland) · 2026
    Article
  8. Targeting SARS-CoV-2 main protease (3CLIn silico pharmacology · 2026
    Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review

11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Abbas KhanDepartment of Bioinformatics and Biological Statistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.ORCID https://orcid.org/0000-0002-4288-7602
Wang HengDepartment of Bioinformatics and Biological Statistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.
Yanjing WangDepartment of Bioinformatics and Biological Statistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.
Jingfei QiuPeng Cheng Laboratory, Shenzhen, China.
Xiaoyong WeiPeng Cheng Laboratory, Shenzhen, China.
Shaoliang PengPeng Cheng Laboratory, Shenzhen, China.
Shoaib SaleemNational Center for Bioinformatics, Quaid-i-Azam University, Islamabad, Pakistan.
Mazhar KhanThe CAS Key Laboratory of Innate Immunity and Chronic Diseases, Hefei National Laboratory for Physical Sciences at Microscale, School of Life Sciences, CAS Center for Excellence in Molecular Cell Science, University of Science and Technology of China (USTC), Collaborative Innovation Center of Genetics and Development, Hefei, China.
Syed Shujait AliCenter for Biotechnology and Microbiology, University of Swat, Swat, Pakistan.
Dong-Qing WeiDepartment of Bioinformatics and Biological Statistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.

Funding

Ministry of Science and Technology of China 2016YFA0501703National Natural Science Foundation of China 32070662Natural Science Foundation of Henan Province 162300410060Science and Technology Commission of Shanghai Municipality 19430750600Shanghai Jiao Tong University YG2017ZD14
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

COVID-19SARS-CoV-2Antiviral AgentsDrug RepositioningHumansKaempferolsMolecular Dynamics SimulationPeptide HydrolasesAntiviral AgentsKaempferolsPeptide Hydrolases

Identifiers

PMID33448101
PMCPMC8013176

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.