Evidence map›Paper›PMID 33447901›Full record

ArticleJournal of molecular neuroscience : MN2021

Nmnat1 Modulates Mitochondrial Oxidative Stress by Inhibiting Caspase-3 Signaling in Alzheimer's Disease.

Huayu Jiang, Zhiwen Wan, Ying Ding, Zhiwen Yao

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of molecular neuroscience : MN, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Huayu Jiang *Department of Neurology, Yangpu Hospital, Tongji University School of Medicine, Shanghai, 200090, China.
Zhiwen Wan *Department of Neurology, Yangpu Hospital, Tongji University School of Medicine, Shanghai, 200090, China.
Ying DingDepartment of Neurology, Yangpu Hospital, Tongji University School of Medicine, Shanghai, 200090, China.
Zhiwen YaoDepartment of Neurology, Yangpu Hospital, Tongji University School of Medicine, Shanghai, 200090, China. zhiwen_yao@163.com.ORCID http://orcid.org/0000-0001-6176-3720
Tongji University · CN

Funding

Yangpu Hospital Sel201807Yangpu Hospital Sel201822
6 · The paper itself

Abstract

Nigrostriatal pathway disturbance is one of the major pathogenic factors in Alzheimer's disease (AD). Dopaminergic neuron dysfunction results in bradykinesia and akinesia (inability to initiate movement), indicating a significant risk factor for substantia nigra pars compacta lesions. Furthermore, the nicotinamide adenine dinucleotide (NAD

Indexed as

Alzheimer DiseaseAnimalsbcl-2-Associated X ProteinCaspase 3Corpus StriatumDopaminergic NeuronsEnzyme ActivationMaze LearningMiceMice, TransgenicMitochondriaNerve Tissue ProteinsNicotinamide-Nucleotide AdenylyltransferaseOpen Field TestOxidative StressProto-Oncogene Proteins c-bcl-2Bax protein, mousebcl-2-Associated X ProteinBcl2 protein, mouseCasp3 protein, mouseCaspase 3Nerve Tissue ProteinsNicotinamide-Nucleotide AdenylyltransferaseNMNAT1 protein, humanNmnat1 protein, mouseProto-Oncogene Proteins c-bcl-2Recombinant ProteinsSod1 protein, mouseSuperoxide Dismutase-1Tyrosine 3-MonooxygenaseAlzheimer’s diseaseDopaminergic neuronsNmnat1Substantia nigraTyrosine hydroxylase (TH)

Identifiers

PMID33447901
OpenAlexW3119883594

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.