Evidence map›Paper›PMID 33447881›Full record

ReviewCell and tissue research2021

The cyclic AMP signaling pathway in the rodent main olfactory system.

Anna Boccaccio, Anna Menini, Simone Pifferi

Abstract readReview
PubMed Publisher
In one paragraph

Review in Cell and tissue research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.

  1. Pooled it
  2. Efficacy of forskolin as a promising therapy for chronic olfactory dysfunction post COVID-19.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024
    Trial
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  8. The CaThe Journal of physiology · 2024
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  13. Sniffing out Ca2+ signaling in olfactory cilia.The Journal of general physiology · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Anna BoccaccioInstitute of Biophysics, National Research Council (CNR), Genova, Italy. anna.boccaccio@ibf.cnr.it.ORCID http://orcid.org/0000-0002-6219-2285
Anna MeniniNeurobiology Group, SISSA, Scuola Internazionale Superiore di Studi Avanzati, Trieste, Italy.ORCID http://orcid.org/0000-0001-9304-0412
Simone PifferiNeurobiology Group, SISSA, Scuola Internazionale Superiore di Studi Avanzati, Trieste, Italy.ORCID http://orcid.org/0000-0002-3687-3984
Marche Polytechnic University · ITNational Research Council · ITScuola Internazionale Superiore di Studi Avanzati · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Odor perception begins with the detection of odorant molecules by the main olfactory epithelium located in the nasal cavity. Odorant molecules bind to and activate a large family of G-protein-coupled odorant receptors and trigger a cAMP-mediated transduction cascade that converts the chemical stimulus into an electrical signal transmitted to the brain. Morever, odorant receptors and cAMP signaling plays a relevant role in olfactory sensory neuron development and axonal targeting to the olfactory bulb. This review will first explore the physiological response of olfactory sensory neurons to odorants and then analyze the different components of cAMP signaling and their different roles in odorant detection and olfactory sensory neuron development.

Indexed as

AnimalsCyclic AMPOlfactory Receptor NeuronsRodentiaCyclic AMPAdaptationCa2+-activated Cl− channelCiliaCNGOlfactory sensory neuronsOlfactory transductionTMEM16

Identifiers

PMID33447881
OpenAlexW3118565549

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.