ArticleBiofilm2020
The evolution from the two stage to the one stage procedure for biofilm based periprosthetic joint infections (PJI).
Article in Biofilm, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Does the duration of antibiotic treatment following one-stage treatment of infected total knee arthroplasty influence the eradication rate? A systematic review.Archives of orthopaedic and trauma surgery · 2024Pooled it
- Clinical and psychosocial impact of limited mobility during the interstage period of two-stage revision arthroplasty for prosthetic joint infection: a state-of-the-art review.Journal of orthopaedic surgery and research · 2026Review
- Short-term outcomes of articular cement spacer in the treatment of prosthetic knee joint infections: a retrospective case series.Singapore medical journal · 2026Article
- Functional biomaterials for the treatment of periprosthetic joint infection: A systematic review of preclinical animal studies.Journal of orthopaedic translation · 2026Review
- Antiseptics' Concentration, Combination, and Exposure Time on Bacterial and Fungal Biofilm Eradication.Arthroplasty today · 2024Article
- One-stage revision for infected shoulder arthroplasty: prospective, observational study of 37 patients.JSES international · 2023Article
- Diagnostic Value of C-Reactive Protein and Serum White Blood Cell Count during Septic Two-Stage Revision of Total Knee Arthroplasties.Antibiotics (Basel, Switzerland) · 2022Article
- Simulated large joint fluid model for evaluating intra-articular antibiotic delivery systems: initial evaluation using antibiotic-loaded calcium sulfate beads.Journal of bone and joint infection · 2022Article
- Utility of Human Neutrophil Lipocalin as a Diagnosing Biomarker of Prosthetic Joint Infection: A Clinical Pilot Study.Infection and drug resistance · 2022Article
- [Septic revision arthroplasty: how to confirm diagnosis, plan surgery and manage follow-up treatment].Der Orthopade · 2021Review
- Sesquiterpene Lactones fromAntibiotics (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A definitive consensus on the optimal limb salvage protocol for infected total joints does not currently exist. Popular, is the two-stage revision which calls for the use of an antibiotic loaded spacer followed by a delayed exchange. Our question is whether single-stage revisions for biofilm based infected arthroplasties results in comparable or possibly better patient outcomes as compared to those reported for two-stage revisions. We retrospectively reviewed 500 cases of one-stage revisions for periprosthetic joint infections (PJI) using dual setup with radical debridement, definitive reconstruction with antibiotic loaded cement and implantation of antibiotic calcium sulfate pellets between the years 2005-2017. The revisions included 351 total knees, 122 hips, 2 hip-femur-knees, 13 shoulders, 10 elbows, and 2 shoulder-humerus-elbows. The patient population had a mean follow-up of 60 months (range: 24 months-14 years) and mean patient age of 61 years old, consisting of 250 males and 250 females. Patient comorbidities were reviewed, classified using McPherson's staging for PJIs, and compared to the Cierny & Mader classification system. Successful treatment was defined as a joint without recurrence of infection, for a minimum of 2 years, and limb preservation. Based on our findings, one-stage revision of PJIs demonstrates at least as good an infection eradication rate as two-stage revision: 88% vs 85% respectively.
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