ArticleBiofilm2020
Weak acids as an alternative anti-microbial therapy.
Article in Biofilm, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 37 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Sweet and sour synergy: exploring the antibacterial and antibiofilm activity of acetic acid and vinegar combined with medical-grade honeys.Microbiology (Reading, England) · 2023Pooled it
- Repassivation of Titanium Surface with Different Disinfectants After Implantoplasty: Effects on Corrosion, Ion Release, Cytotoxicity and Bacterial Behaviour-An In Vitro Study.Dentistry journal · 2026Article
- Management of post-operative pseudomonas aeruginosa infection in head and neck free flap patients: Systematic review and case series.JPRAS open · 2026Article
- "Antimicrobial Brachytherapy" Protocol for Chronic Periprosthetic Joint Infection in Total Knee Arthroplasty: A Preliminary Case Series with 2-Year Results.Journal of clinical medicine · 2026Article
- Tissue Regeneration on Implantoplasty-Treated Implants Using a Citric Acid-Collagen-Magnesium-Based Solution: An In Vitro and In Vivo Study.Biomimetics (Basel, Switzerland) · 2026Article
- Potential Antidiabetic Inhibitors and Antimicrobials from the FungusJournal of microbiology and biotechnology · 2025Article
- In Vitro Assessment of a Novel Piranha-Passivated Dental Implant Surface Against Oral Biofilm Formation.Clinical oral implants research · 2025Article
- Candida albicans colonization in the human colon correlates with a reduction in acetate- and butyrate-producing bacteria, as simulated using the M-SHIME® model.NPJ biofilms and microbiomes · 2025Article
- Alginate exopolymer significantly modulates the viscoelastic properties and resilience of bacterial biofilms.NPJ biofilms and microbiomes · 2025Article
- Article
- "Candidatus Liberibacter asiaticus" Infection Induces Citric Acid Accumulation and Immune Responses Mediated by the Transcription Factor CitPH4.Molecular plant pathology · 2025Article
- From Soil to Salad: Strategies for Reducing Foodborne Illness Outbreaks.Food science & nutrition · 2025Review
- The Results of Intestinal Villi of Laying Hens Exposed With Avian PathogenicVeterinary medicine international · 2025Article
- High-performance liquid chromatography method for measuring Captopril: an empirical study on hydrogel film permeability test.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2024Article
- Mechanistic Insights into Succinic Acid as an Adjuvant for Ciprofloxacin in TreatingMicroorganisms · 2024Article
- Potency of butylated hydroxytoluene and optimized black pepper extract as additives on quality characteristics of stored (4 °C) pork on various days.Food science and biotechnology · 2024Article
- New proportion of levofloxacin citrate: Structural, physicochemical properties, and potency studies.Heliyon · 2024Article
- Study of the Resistance ofInternational journal of molecular sciences · 2024Article
- Citric Acid Controls the Activity of YopH Bacterial Tyrosine Phosphatase.Drug design, development and therapy · 2024Article
- Multi-Strain Probiotics Enhance the Bioactivity of Cascara Kombucha during Microbial Composition-Controlled Fermentation.Preventive nutrition and food science · 2023Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Weak acids such as acetic acid and N-acetyl cysteine (NAC) at pH less than their pKa can effectively eradicate biofilms due to their ability to penetrate the biofilm matrix and the cell membrane. However, the optimum conditions for their activity against drug resistant strains, and safety, need to be understood for their application to treat infections or to inactivate biofilms on hard surfaces. Here, we investigate the efficacy and optimum conditions at which weak acids can eradicate biofilms. We compared the efficacy of various mono and triprotic weak acids such as N-acetyl cysteine (NAC), acetic acid, formic acid and citric acid, in eradicating biofilms. We found that monoprotic weak acids/acid drugs can kill mucoid
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.