Evidence map›Paper›PMID 33447791›Full record

ArticleBiofilm2019

Laser-induced vapor nanobubbles improve diffusion in biofilms of antimicrobial agents for wound care.

E Teirlinck, J C Fraire, H Van Acker, J Wille, R Swimberghe, T Brans, R Xiong, M Meire, R J G De Moor, S C De Smedt and 2 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biofilm, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 28 citations in OpenAlex.

  1. Review
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  6. Inactivation ofFoods (Basel, Switzerland) · 2020
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

E TeirlinckLaboratory of General Biochemistry and Physical Pharmacy, University of Ghent, Ghent, 9000, Belgium.
J C FraireLaboratory of General Biochemistry and Physical Pharmacy, University of Ghent, Ghent, 9000, Belgium.
H Van AckerLaboratory of Pharmaceutical Microbiology, University of Ghent, Ghent, 9000, Belgium.
J WilleLaboratory of Pharmaceutical Microbiology, University of Ghent, Ghent, 9000, Belgium.
R SwimbergheDepartment of Oral Health Sciences, Section of Endodontology, University of Ghent, Ghent, 9000, Belgium.
T BransLaboratory of General Biochemistry and Physical Pharmacy, University of Ghent, Ghent, 9000, Belgium.
R XiongLaboratory of General Biochemistry and Physical Pharmacy, University of Ghent, Ghent, 9000, Belgium.
M MeireDepartment of Oral Health Sciences, Section of Endodontology, University of Ghent, Ghent, 9000, Belgium.
R J G De MoorDepartment of Oral Health Sciences, Section of Endodontology, University of Ghent, Ghent, 9000, Belgium.
S C De SmedtLaboratory of General Biochemistry and Physical Pharmacy, University of Ghent, Ghent, 9000, Belgium.
T CoenyeLaboratory of Pharmaceutical Microbiology, University of Ghent, Ghent, 9000, Belgium.
K BraeckmansLaboratory of General Biochemistry and Physical Pharmacy, University of Ghent, Ghent, 9000, Belgium.
Ghent University · BEUniversité de Lille · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Being responsible for delayed wound healing, the presence of biofilms in infected wounds leads to chronic, and difficult to treat infections. One of the reasons why antimicrobial treatment often fails to cure biofilm infections is the reduced penetration rate of antibiotics through dense biofilms. Strategies that have the ability to somehow interfere with the integrity of biofilms and allowing a better penetration of drugs are highly sought after. A promising new approach is the use of laser-induced vapor nanobubbles (VNB), of which it was recently demonstrated that it can substantially enhance the penetration of antibiotics into biofilms, resulting in a marked improvement of the killing efficiency. In this study, we examined if treatment of biofilms with laser-induced vapor nanobubbles (VNB) can enhance the potency of antimicrobials which are commonly used to treat wound infections, including povidone-iodine, chlorhexidine, benzalkonium chloride, cetrimonium bromide and mupirocin. Our investigations were performed on

Indexed as

BiofilmsDiffusion barrierDisinfectantsLaser treatmentVapor nanobubblesWound infections

Identifiers

PMID33447791
PMCPMC7798460
OpenAlexW2966666332

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.