ArticleInternational Journal of Cardiology. Hypertension2019
The relationship between chronic stress, hair cortisol and hypertension.
Article in International Journal of Cardiology. Hypertension, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Establishment of a reference range for hair cortisol using a HPLC-MS/MS method in a Northern Italian population.Journal of endocrinological investigation · 2026Article
- Intersecting Structural Barriers and Hypertension Management Among Middle East and North Africa Refugees Resettled in the United States: A Qualitative Study.Health education & behavior : the official publication of the Society for Public Health Education · 2025Article
- Association between the psychological frailty index and stroke: a cohort study from CHARLS.Scientific reports · 2025Article
- Transcutaneous auricular vagus nerve stimulation inhibits mental stress-induced cortisol release-Potential implications for inflammatory conditions.Physiological reports · 2025Article
- Chronic stress and hair cortisol concentration in mothers: A two-study investigation.Stress and health : journal of the International Society for the Investigation of Stress · 2024Article
- Work environment and hypertension in industrial settings in Benin in 2019: a cross-sectional study.BMJ open · 2024Article
- Conceptualizing the Biopsychosocial-Spiritual Health Influences of Adverse Childhood Experiences and the Application of Primary Care Behavioral Health for Their Treatment.Journal of religion and health · 2024Review
- Effect of alcohol consumption on breast cancer: probabilistic bias analysis for adjustment of exposure misclassification bias and confounders.BMC medical research methodology · 2023Article
- Formerly bile-farmed bears as a model of accelerated ageing.Scientific reports · 2023Article
- A cohort study on the association between changing occupational stress, hair cortisol concentration, and hypertension.PloS one · 2023Article
- Psychosocial and environmental risk factors of obesity and hypertension in children and adolescents-a literature overview.Frontiers in cardiovascular medicine · 2023Review
- Prevalence, Treatment, and Control of Hypertension Among US Women of Reproductive Age by Race/Hispanic Origin.American journal of hypertension · 2022Article
- Hypertensive Disorders in Pregnancy and Mortality at Delivery Hospitalization - United States, 2017-2019.MMWR. Morbidity and mortality weekly report · 2022Article
- Chronic Stress and Depression in Periodontitis and Peri-Implantitis: A Narrative Review on Neurobiological, Neurobehavioral and Immune-Microbiome Interplays and Clinical Management Implications.Dentistry journal · 2022Review
- Higher Levels of Stress-Related Hair Steroid Hormones Are Associated with the Increased SCORE2 Risk Prediction Algorithm in Apparently Healthy Women.Journal of cardiovascular development and disease · 2022Article
- The Survey of the Health of Wisconsin (SHOW) Program: An Infrastructure for Advancing Population Health.Frontiers in public health · 2022Article
- Depression and Dementia: The Role of Cortisol and Vascular Brain Lesions. AGES-Reykjavik Study.Journal of Alzheimer's disease : JAD · 2022Article
- The psychobiological links between chronic stress-related diseases, periodontal/peri-implant diseases, and wound healing.Periodontology 2000 · 2021Review
- Stress and Molecular Drivers for Cancer Progression: A Longstanding Hypothesis.Biomedical journal of scientific & technical research · 2021Article
- The Survey of the Health of Wisconsin (SHOW) Program: An infrastructure for Advancing Population Health Sciences.medRxiv : the preprint server for health sciences · 2021Article
Corrections and comments
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Authors and funding
6 authors.
Funding
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Abstract
Inconsistencies in studies of chronic psychosocial stress and hypertension may be explained by the use of stress markers greatly influenced by circadian rhythm and transient stressors. We assessed whether hair cortisol, a marker that captures systemic cortisol over months, was independently associated with hypertension. We measured hair cortisol and blood pressure in 75 consecutive participants in the Survey of the Health of Wisconsin, using an ELISA test. Individuals with values ≥ median (78.1 pg/mg) were considered exposed. We used approximate Bayesian logistic regression, with a prior odds ratio of 1.0-4.0, to quantify the multivariate-adjusted hair cortisol-hypertension association. Participants' average age was 46.9 years; 37.3% were male; and 25.3% were hypertensive. Hypertension prevalence was 2.23 times higher in exposed (95% CI: 1.69-3.03). This finding was unlikely explained by differential measurement errors, since we conducted blinded measurements of exposure and outcome. Sensitivity analyses showed the association was unlikely explained by an unmeasured confounder, survival bias, or reverse causality bias. Findings suggest elevated hair cortisol is a risk factor for hypertension. Although feasible, the clinical value of hair cortisol as a tool for hypertension risk stratification or for monitoring the effect of chronic psychosocial stress management interventions is still uncertain.
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