ArticleInternational Journal of Cardiology. Hypertension2019
Impact of uric acid on incident hypertension: Sex-specific analysis in different age groups.
Article in International Journal of Cardiology. Hypertension, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Gender Differences in the Associations Between Serum Urate and Cardiometabolic Risk Factors in Age-Matched Middle-Aged Japanese.Women's health reports (New Rochelle, N.Y.) · 2025Article
- Sex-specific associations between serum uric acid levels and risk of hypertension for different diagnostic reference values of high blood pressure.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Role of asymptomatic hyperuricemia in the progression of chronic kidney disease and cardiovascular disease.The Korean journal of internal medicine · 2021Review
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Authors and funding
8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The aim of the present study is to evaluate the association of serum uric acid (UA) levels with the risk of incident hypertension among different age groups in men and women using a single large Japanese general cohort. The present study is based on annual health check-up program in Gunma, Japan. We studied 12,029 participants (mean age, 48 ± 9 years old; 31% women) free of prevalent cardiovascular disease and hypertension at baseline (2009). Hypertension was defined by self-report, hypertensive medication use, or measured BP > 140/90 mmHg at each visit. Discrete proportional hazards regression model was used to evaluate the association of UA level at baseline with incident hypertension through 2012 adjusted for age, gender, baseline blood pressure, and other CVD risk factors among different age decade groups in men and women. During follow-up of 3 years, 12% of the cohort (n = 1457) developed hypertension. UA was strongly associated with incident hypertension in the multivariable model in all participants. In age-stratified analysis, participants below 50 years of age in men had the significant association of UA with incident hypertension, whereas participants above 50 years did not. In women, participants above 40 years had the significant association, whereas participants below 40 years did not. The present data suggest that UA level is an independent predictor for incident hypertension among middle aged men below 50 years old and middle aged and the elderly women above 40 years.
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