ReviewJournal of spine surgery (Hong Kong)2020
Antibiotic treatment of postoperative spinal implant infections.
Review in Journal of spine surgery (Hong Kong), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- Nomogram for predicting inadequate treatment response in vertebral osteomyelitis.Annals of medicine · 2026Article
- The Microbiology of Postoperative Spine Surgical Site Infections: An Institutional Experience of 170 cases.Journal of clinical orthopaedics and trauma · 2026Article
- Surgical Site Infection, Microbiology, and Antibiotic Utilization After Posterior Cervical Spinal Decompression and Fusion: A 10-Year Experience.Global spine journal · 2026Article
- Two-Year Outcomes of Postoperative Spine Infection: Implant Retention and Predictors of Treatment Failure.Open forum infectious diseases · 2026Article
- Synergistic effect of copper(ii) ions and orthosilicate group in nanosized hydroxyapatite.RSC advances · 2026Article
- Suppressive antibiotic therapy for spinal hardware infection: a retrospective cohort study.BMC infectious diseases · 2026Article
- Synergistic integration of biomaterials in orthopedic implantation for infection preventing and tissue engineering.Regenerative biomaterials · 2026Review
- Spinal infections.Frontiers in neuroscience · 2026Review
- Assessment of Sonication for Diagnosing Implant-Associated Infections in Spinal Surgery Routine Practice.Microorganisms · 2025Article
- Combination Antibiotic Therapy for Orthopedic Infections.Antibiotics (Basel, Switzerland) · 2025Review
- Clinical features and management of postoperative lumbar intervertebral space infections following spinal endoscopy: a retrospective analysis.Frontiers in cellular and infection microbiology · 2025Article
- Risk-Adapted Use of Vancomycin in Secondary Scoliosis Surgery May Normalize SSI Risk in Surgical Correction of High-Risk Patients.Journal of personalized medicine · 2024Article
- Superinfections of the Spine: A Single-Institution Experience.Journal of clinical medicine · 2024Article
- [Surgical treatment of high-grade spondylolisthesis].Operative Orthopadie und Traumatologie · 2024Review
- A Review of the Clinical Utilization of Oral Antibacterial Therapy in the Treatment of Bone Infections in Adults.Antibiotics (Basel, Switzerland) · 2023Review
- An Assessment of the Safety of Surgery and Hardware Placement in de-novo Spinal Infections. A Systematic Review and Meta-Analysis of the Literature.Global spine journal · 2023Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Postoperative spinal implant infection (PSII) is a serious complication after spinal surgery. It is associated with increased morbidity and mortality for affected patients as well as significant costs for the healthcare system. Due to the formation of biofilm on foreign material, both diagnosis and treatment of PSII can pose a considerable challenge. Modern treatment protocols allow efficient eradication and good clinical outcomes in the majority of patients. In this article, we review the current antibiotic treatment concepts for PSII including the correct choice of antibiotics and their combination. In cases of late-onset PSII where the implants can be removed, two weeks of intravenous (IV) antibiotics followed by 4 weeks of oral antibiotics seem appropriate. If the implant needs to be retained, a 2-week IV antibiotic treatment should be followed by 10 weeks of oral antibiotic therapy with biofilm activity or, in case of problematic pathogens, a long-term suppression therapy. Initial empiric antibiotic therapy should cover staphylococci, streptococci, enterococci and Gram-negative bacilli as the most common pathogens. Antibiotic adjustments according to the type of pathogen and its antimicrobial susceptibility are essential for successful eradication of infection.
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