ArticleOpen forum infectious diseases2021
Diagnostic and Prognostic Utility Compared Among Different Sepsis Scoring Systems in Adult Patients With Sepsis in Thailand: A Prospective Cohort Study.
Article in Open forum infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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12 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- National Early Warning Score Does Not Accurately Predict Mortality for Patients With Infection Outside the Intensive Care Unit: A Systematic Review and Meta-Analysis.Frontiers in medicine · 2021Pooled it
- Association between lactate clearance rate and 28-day mortality in patients with sepsis: a retrospective cohort study and exploration of an optimal lactate clearance as an endpoint of resuscitation.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2026Article
- Diagnostic Accuracy of Simplified Prehospital Sepsis Screening Tools for Identifying Sepsis and Predicting 30-Day Mortality: A Retrospective Diagnostic Accuracy Study.Clinical epidemiology · 2026Article
- Performance of Early Sepsis Screening Tools for Timely Diagnosis and Antibiotic Stewardship in a Resource-Limited Thai Community Hospital.Antibiotics (Basel, Switzerland) · 2025Article
- Improved Interpretability Without Performance Reduction in a Sepsis Prediction Risk Score.Diagnostics (Basel, Switzerland) · 2025Article
- Study of the Role of C-reactive Protein/Procalcitonin Ratio as a Prognostic Tool in ICU Patients with Sepsis: A Prospective Observational Study.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2024Article
- Prognostic Accuracy of Screening Tools for Clinical Deterioration in Adults With Suspected Sepsis in Northeastern Thailand: A Cohort Validation Study.Open forum infectious diseases · 2024Article
- Navigating the Complexity of Scoring Systems in Sepsis Management: A Comprehensive Review.Cureus · 2024Review
- Prognostic evaluation of quick sequential organ failure assessment score in ICU patients with sepsis across different income settings.Critical care (London, England) · 2024Observational
- Article
- Epidemiology and Burden of Sepsis at Thailand's Largest University-Based National Tertiary Referral Center during 2019.Antibiotics (Basel, Switzerland) · 2022Article
- A comparison of different scores for diagnosis and mortality prediction of adults with sepsis in Low-and-MiddleEClinicalMedicine · 2021Article
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6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe diagnostic and prognostic utility of various sepsis scores varied among different cohorts and settings.
methodsA prospective cohort study in adult patients with sepsis at Siriraj Hospital (Bangkok, Thailand) was conducted during January to July 2019. The performance of sepsis assessments, including systemic inflammatory response syndrome (SIRS) score, sequential organ failure assessment (SOFA) score, quick sepsis-related organ failure assessment (qSOFA) score, modified early warning score (MEWS), and national early warning score (NEWS), for sepsis detection and mortality prediction were compared with agreement between 2 infectious disease (ID) specialists to determine their sepsis and septic shock status as the reference standard.
resultsAmong the 470 subjects included in this study, 206 patients (43.8%) were determined by 2 ID specialists to have sepsis. Systemic inflammatory response syndrome ≥2, qSOFA ≥2, and NEWS ≥5 yielded the highest sensitivity (93.2%), specificity (81.3%), and accuracy (72.6%), respectively, for detecting sepsis. The SIRS ≥2 had the highest sensitivity (97.8%), whereas qSOFA ≥2 had the highest specificity (61%) and accuracy (69.7%) for predicting mortality among sepsis patients. Receiver operating characteristic (ROC) curve showed MEWS to have the highest discriminatory power for sepsis detection (area under the ROC curve [AUROC], 0.79; 95% confidence interval [CI], 0.74-0.83), whereas SOFA had the highest discriminatory power for predicting hospital mortality (AUROC, 0.76; 95% CI, 0.69-0.79).
conclusionsThe NEWS ≥5 and qSOFA ≥2 were the most accurate scoring systems for sepsis detection and mortality prediction, respectively. Each scoring system is useful for different specific purposes relative to early detection and mortality prediction in sepsis patients.
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