ArticleOpen forum infectious diseases2021
Sleep Disorders in Human Immunodeficiency Virus: A Substudy of the Pharmacokinetics and Clinical Observations in People Over Fifty (POPPY) Study.
Article in Open forum infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The prevalence and moderating factors of sleep disturbances in people living with HIV: a systematic review and meta-analysis.Scientific reports · 2024Pooled it
- Changes in cerebral function parameters in persons with HIV with symptoms of insomnia switching from dolutegravir- to bictegravir-based antiretroviral therapy.Journal of neurovirology · 2025Trial
- Prevalence of neurotoxicity symptoms among postpartum women on isoniazid preventive therapy and efavirenz-based treatment for HIV: an exploratory objective of the IMPAACT P1078 randomized trial.BMC pregnancy and childbirth · 2023Trial
- Prevalence of Sleep Apnea and Sleepiness in Adults With and Without HIV in Mwanza, Tanzania: Baseline Results From an Ongoing Cohort Study.Journal of sleep research · 2026Article
- Associations between plasma biomarkers and changes in cognitive function over two years in people with and without HIV.AIDS (London, England) · 2026Article
- Southern African HIV Clinicians Society clinical guideline for the management of older people with HIV.Southern African journal of HIV medicine · 2026Article
- Risk of Psychiatric Morbidity in People Living With Human Immunodeficiency Virus: A Population-Based Cohort Study.Psychiatry investigation · 2026Article
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- Article
- Poor sleep and hepatic steatosis contribute to poorer quality of life in people with human immunodeficiency virus.World journal of gastroenterology · 2025Observational
- Sleep Disturbance Mediates the Associations Between HIV Stigma and Mental and Physical Health Among Black Adults with HIV.Journal of racial and ethnic health disparities · 2025Article
- Associations between multimorbidity burden and objective and patient-reported sleep outcomes among people with HIV.AIDS (London, England) · 2025Article
- Article
- Article
- Unveiling the pathophysiology of restless legs syndrome through transcriptome analysis.iScience · 2024Article
- Sleep deficiency among people living with human immunodeficiency virus: A growing challenge.HIV medicine · 2024Review
- Prevalence of pain in women living with HIV aged 45-60: associated factors and impact on patient-reported outcomes.AIDS care · 2023Article
- Article
- Time of Day Influences Concentrations of Total Protein and Albumin in Cerebrospinal Fluid in HIV.International journal of molecular sciences · 2023Article
- Current Challenges and Solutions for Clinical Management and Care of People with HIV: Findings from the 12th Annual International HIV and Aging Workshop.AIDS research and human retroviruses · 2023Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
backgroundSelf-reported sleep quality is poor in persons with human immunodeficiency virus (PWH), but prior studies commonly used nonspecific questionnaires, investigated only single sleep disorders, or lacked human immunodeficiency virus (HIV)-negative controls. We addressed these limitations in the Pharmacokinetics and Clinical Observations in People Over Fifty (POPPY) Sleep Substudy by assessing PWH and HIV-negative controls for insomnia, restless legs syndrome (RLS), and sleep apnea (SA).
methodsPreviously enrolled POPPY participants coenrolled in this substudy without regard to sleep symptoms. Participants completed validated sleep assessments including the Insomnia Severity Index questionnaire, International Restless Legs Syndrome Study Group questionnaire, and in-home, wrist-worn overnight oximetry. They also completed health-related quality of life questionnaires including 36-item Short Form (SF-36) and Patient-Reported Outcomes Measurement Information System (PROMIS) sleep questionnaires.
resultsWe enrolled 357 PWH (246 >50 years of age; 111 between 18 and 50 years) and 126 HIV-negative controls >50 years of age. Among PWH, criteria were met by 21% for insomnia, 13% for RLS, and 6% for SA. Compared with HIV-negative controls, PWH had a higher risk of insomnia (adjusted odds ratio, 5.3; 95% confidence interval, 2.2-12.9) but not RLS or SA. Compared with PWH without insomnia, those with insomnia reported significantly worse scores on all SF-36 and PROMIS components; fewer than 30% reported previous diagnosis or treatment for insomnia.
conclusionsInsomnia was more common in PWH, associated with worse health-related quality of life, and frequently undiagnosed. Further research should focus on the pathogenesis of insomnia in PWH and the development of effective screening and intervention strategies for this unique population.
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